STRINGSTRING
recA recA polA polA lexA lexA umuD umuD uvrD uvrD sms sms umuC umuC topA topA ABM70020.1 ABM70020.1 recN recN cinA cinA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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recARecA bacterial DNA recombination protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (365 aa)    
Predicted Functional Partners:
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.990
lexA
SOS function regulatory protein, LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
  
 
 0.930
umuD
Putative SOS mutagenesis protein UmuD; COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Belongs to the peptidase S24 family.
  
 
 0.889
uvrD
UvrD/REP helicase; COG210 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].
  
 
 0.877
sms
Putative DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
   
  
 0.836
umuC
Putative UmuC protein; COG389 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair].
  
 0.819
topA
Prokaryotic DNA topoisomerase; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removin [...]
  
 0.786
ABM70020.1
Putative transcripton factor.
  
 0.777
recN
DNA repair protein RecN, ABC transporter; May be involved in recombinational repair of damaged DNA.
  
  
 0.750
cinA
Molybdenum cofactor biosynthesis protein; COG1058 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Belongs to the CinA family.
  
  
 0.657
Your Current Organism:
Prochlorococcus marinus AS9601
NCBI taxonomy Id: 146891
Other names: P. marinus str. AS9601, Prochlorococcus marinus str. AS9601, Prochlorococcus sp. AS9601
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