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gcvT gcvT gcvH1 gcvH1 gcvP1 gcvP1 gcvP2 gcvP2 gcvH2 gcvH2 glyA glyA aceF aceF folD folD purH purH lpd lpd purN purN
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
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experimentally determined
Predicted Interactions
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gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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gcvTGlycine cleavage complex protein T (aminomethyltransferase); The glycine cleavage system catalyzes the degradation of glycine. (358 aa)    
Predicted Functional Partners:
gcvH1
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 0.999
gcvP1
Glycine cleavage system P protein, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
 
 0.999
gcvP2
Similar to Q83B09 Putative glycine cleavage system P protein, subunit 2 from Coxiella burnetii (491 aa). FASTA: opt: 2055 Z-score: 2482.9 E(): 2.1e-130 Smith-Waterman score: 2055; 63.071identity in 482 aa overlap.
 0.999
gcvH2
Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 0.997
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
 
 0.996
aceF
Pyruvate dehydrogenase, E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 0.991
folD
Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
  
 
 0.955
purH
Similar to PUR9_RHIME (Q92KX6) Bifunctional purine biosynthesis purH from Rhizobium meliloti (536 aa). FASTA: opt: 1834 Z-score: 2200.5 E(): 1.1e-114 Smith-Waterman score: 1834; 55.344identity in 524 aa overlap Includes phosphoribosylaminoimidazolecarboxyamide formyltransferase and IMP synthetase.
   
 
 0.940
lpd
Transposase, fragement; 9 bp terminal inverse repeat.
  
 0.936
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
   
 
 0.932
Your Current Organism:
Francisella tularensis SCHUS4
NCBI taxonomy Id: 177416
Other names: F. tularensis subsp. tularensis SCHU S4, Francisella tularensis Biovar A str. SCHU S4, Francisella tularensis Biovar A str. Schu 4, Francisella tularensis subsp. tularensis SCHU S4, Francisella tularensis subsp. tularensis Schu 4, Francisella tularensis subsp. tularensis str. SCHU S4, Francisella tularensis subsp. tularensis strain SCHU S4
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