node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aceF | folD | FTT_1484c | FTT_0892 | Pyruvate dehydrogenase, E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.604 |
aceF | gcvH1 | FTT_1484c | FTT_0408 | Pyruvate dehydrogenase, E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.501 |
aceF | gcvH2 | FTT_1484c | FTT_0812 | Pyruvate dehydrogenase, E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.501 |
aceF | gcvP1 | FTT_1484c | FTT_0409 | Pyruvate dehydrogenase, E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Glycine cleavage system P protein, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.881 |
aceF | gcvP2 | FTT_1484c | FTT_0410 | Pyruvate dehydrogenase, E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Similar to Q83B09 Putative glycine cleavage system P protein, subunit 2 from Coxiella burnetii (491 aa). FASTA: opt: 2055 Z-score: 2482.9 E(): 2.1e-130 Smith-Waterman score: 2055; 63.071identity in 482 aa overlap. | 0.957 |
aceF | gcvT | FTT_1484c | FTT_0407 | Pyruvate dehydrogenase, E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Glycine cleavage complex protein T (aminomethyltransferase); The glycine cleavage system catalyzes the degradation of glycine. | 0.991 |
aceF | glyA | FTT_1484c | FTT_1241 | Pyruvate dehydrogenase, E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.771 |
aceF | lpd | FTT_1484c | FTT_1483c | Pyruvate dehydrogenase, E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Transposase, fragement; 9 bp terminal inverse repeat. | 0.999 |
aceF | purH | FTT_1484c | FTT_0203c | Pyruvate dehydrogenase, E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Similar to PUR9_RHIME (Q92KX6) Bifunctional purine biosynthesis purH from Rhizobium meliloti (536 aa). FASTA: opt: 1834 Z-score: 2200.5 E(): 1.1e-114 Smith-Waterman score: 1834; 55.344identity in 524 aa overlap Includes phosphoribosylaminoimidazolecarboxyamide formyltransferase and IMP synthetase. | 0.620 |
folD | aceF | FTT_0892 | FTT_1484c | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Pyruvate dehydrogenase, E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.604 |
folD | gcvP2 | FTT_0892 | FTT_0410 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Similar to Q83B09 Putative glycine cleavage system P protein, subunit 2 from Coxiella burnetii (491 aa). FASTA: opt: 2055 Z-score: 2482.9 E(): 2.1e-130 Smith-Waterman score: 2055; 63.071identity in 482 aa overlap. | 0.639 |
folD | gcvT | FTT_0892 | FTT_0407 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage complex protein T (aminomethyltransferase); The glycine cleavage system catalyzes the degradation of glycine. | 0.955 |
folD | glyA | FTT_0892 | FTT_1241 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.981 |
folD | purH | FTT_0892 | FTT_0203c | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Similar to PUR9_RHIME (Q92KX6) Bifunctional purine biosynthesis purH from Rhizobium meliloti (536 aa). FASTA: opt: 1834 Z-score: 2200.5 E(): 1.1e-114 Smith-Waterman score: 1834; 55.344identity in 524 aa overlap Includes phosphoribosylaminoimidazolecarboxyamide formyltransferase and IMP synthetase. | 0.965 |
folD | purN | FTT_0892 | FTT_0895 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.979 |
gcvH1 | aceF | FTT_0408 | FTT_1484c | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Pyruvate dehydrogenase, E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.501 |
gcvH1 | gcvH2 | FTT_0408 | FTT_0812 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.907 |
gcvH1 | gcvP1 | FTT_0408 | FTT_0409 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine cleavage system P protein, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.999 |
gcvH1 | gcvP2 | FTT_0408 | FTT_0410 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Similar to Q83B09 Putative glycine cleavage system P protein, subunit 2 from Coxiella burnetii (491 aa). FASTA: opt: 2055 Z-score: 2482.9 E(): 2.1e-130 Smith-Waterman score: 2055; 63.071identity in 482 aa overlap. | 0.998 |
gcvH1 | gcvT | FTT_0408 | FTT_0407 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine cleavage complex protein T (aminomethyltransferase); The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |