STRINGSTRING
tylMIII tylMIII KDS89028.1 KDS89028.1 tylMII tylMII KDS89038.1 KDS89038.1 KDS89039.1 KDS89039.1 tylCV tylCV KDS85912.1 KDS85912.1 KDS88685.1 KDS88685.1 KDS83975.1 KDS83975.1 KDS89037.1 KDS89037.1 KDS87472.1 KDS87472.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
tylMIIIHypothetical protein; Involved in the biosynthesis of the macrolide antibiotic tylosin derived from the polyketide lactone tylactone. TylM3 is required for the glycosylation of the 5-hydroxyl group of tylactone to yield 5-O-mycaminosytylactone; Belongs to the cytochrome P450 family. (423 aa)    
Predicted Functional Partners:
KDS89028.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
  
 0.999
tylMII
Glycosyl transferase family 28; Involved in the biosynthesis of the macrolide antibiotic tylosin derived from the polyketide lactone tylactone. Catalyzes the transfer of alpha-D-mycaminosyl from dTDP-alpha-D-mycaminose to the 5- hydroxyl group of tylactone to yield 5-O-mycaminosytylactone. It can also accept 16-membered tylactone and 12-membered ring macrolide. Belongs to the glycosyltransferase 28 family.
   
 0.995
KDS89038.1
Amino acid adenylation protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.987
KDS89039.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.987
tylCV
Hypothetical protein; Involved in the biosynthesis of mycarose which is a 6- deoxyhexose sugar required during production of the macrolide antibiotic tylosin. Catalyzes the transfer of L-mycarosyl from dTDP- beta-L-mycarose to demethyllactenocin to yield demethylmacrocin.
 
 
 0.982
KDS85912.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
   
 0.979
KDS88685.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
  
 0.977
KDS83975.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.963
KDS89037.1
Amino acid adenylation protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.959
KDS87472.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.959
Your Current Organism:
Streptomyces fradiae
NCBI taxonomy Id: 1906
Other names: ATCC 10745, ATCC 19760, Actinomyces fradii, BCRC 12196, CBS 498.68, CCM 3174, CCRC 12196, CCRC:12196, CECT 3197, DSM 40063, HAMBI 965, HUT 6095, IFO 12773, IFO 3718, IMET 42051, IMI 061202, ISP 5063, JCM 4133, JCM 4579, JCM 4824 [[Streptomyces roseoflavus]], KCTC 9760, NBRC 12773, NBRC 13439 [[Streptomyces roseoflavus]], NBRC 3718, NCIMB 11005, NCIMB 8233, NRRL B-2789 [[Streptomyces roseoflavus]], NRRL-ISP 5063, PCM 2330, RIA 97, S. fradiae, Streptomyces fradiae subsp. fradiae, Streptomyces fradii, Streptomyces roseiflavus, Streptomyces roseoflavus, Streptomyces sp. NEAE-82, UNIQEM 146, VKM Ac-150, VKM Ac-151, VKM Ac-152, VKM Ac-764
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