STRINGSTRING
tylMII tylMII tylMIII tylMIII tylM1 tylM1 KDS89028.1 KDS89028.1 KDS84465.1 KDS84465.1 KDS83996.1 KDS83996.1 KDS83992.1 KDS83992.1 KDS83991.1 KDS83991.1 KDS84462.1 KDS84462.1 KDS84459.1 KDS84459.1 KDS89380.1 KDS89380.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
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[Homology]
Score
tylMIIGlycosyl transferase family 28; Involved in the biosynthesis of the macrolide antibiotic tylosin derived from the polyketide lactone tylactone. Catalyzes the transfer of alpha-D-mycaminosyl from dTDP-alpha-D-mycaminose to the 5- hydroxyl group of tylactone to yield 5-O-mycaminosytylactone. It can also accept 16-membered tylactone and 12-membered ring macrolide. Belongs to the glycosyltransferase 28 family. (432 aa)    
Predicted Functional Partners:
tylMIII
Hypothetical protein; Involved in the biosynthesis of the macrolide antibiotic tylosin derived from the polyketide lactone tylactone. TylM3 is required for the glycosylation of the 5-hydroxyl group of tylactone to yield 5-O-mycaminosytylactone; Belongs to the cytochrome P450 family.
   
 0.995
tylM1
SAM-dependent methyltransferase; S-adenosyl-L-methionine-dependent methyltransferase involved in the biosynthesis of mycaminose, an essential structural component of the macrolide antibiotic tylosin. Involved in the last step in mycaminose biosynthesis by mediating dimethylation of the hexose C-3' amino group; Belongs to the methyltransferase TylM1/DesVI family.
 
  
 0.874
KDS89028.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
 
 
 0.845
KDS84465.1
NDP-hexose 2,3-dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.821
KDS83996.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
       0.768
KDS83992.1
Polyketide synthase subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
    0.704
KDS83991.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.698
KDS84462.1
Glucose-1-phosphate thymidylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.636
KDS84459.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.617
KDS89380.1
Cytochrome P450; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.585
Your Current Organism:
Streptomyces fradiae
NCBI taxonomy Id: 1906
Other names: ATCC 10745, ATCC 19760, Actinomyces fradii, BCRC 12196, CBS 498.68, CCM 3174, CCRC 12196, CCRC:12196, CECT 3197, DSM 40063, HAMBI 965, HUT 6095, IFO 12773, IFO 3718, IMET 42051, IMI 061202, ISP 5063, JCM 4133, JCM 4579, JCM 4824 [[Streptomyces roseoflavus]], KCTC 9760, NBRC 12773, NBRC 13439 [[Streptomyces roseoflavus]], NBRC 3718, NCIMB 11005, NCIMB 8233, NRRL B-2789 [[Streptomyces roseoflavus]], NRRL-ISP 5063, PCM 2330, RIA 97, S. fradiae, Streptomyces fradiae subsp. fradiae, Streptomyces fradii, Streptomyces roseiflavus, Streptomyces roseoflavus, Streptomyces sp. NEAE-82, UNIQEM 146, VKM Ac-150, VKM Ac-151, VKM Ac-152, VKM Ac-764
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