node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CC_1727 | CC_2100 | CC_1727 | CC_2100 | Pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Acetolactate synthase, large subunit; Identified by match to TIGR protein family HMM TIGR00118. | 0.849 |
CC_1727 | CC_2622 | CC_1727 | CC_2622 | Pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | NADP-dependent malic enzyme; Identified by match to PFAM protein family HMM PF01515. | 0.969 |
CC_1727 | CC_3399 | CC_1727 | CC_3399 | Pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Threonine synthase; Identified by match to TIGR protein family HMM TIGR00260. | 0.423 |
CC_1727 | IlvH | CC_1727 | CC_2101 | Pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Acetolactate synthase, small subunit; Identified by match to TIGR protein family HMM TIGR00119. | 0.864 |
CC_1727 | ilvE | CC_1727 | CC_2929 | Pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.744 |
CC_1727 | leuA | CC_1727 | CC_1541 | Pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.874 |
CC_1727 | leuB | CC_1727 | CC_0193 | Pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.482 |
CC_1727 | leuC | CC_1727 | CC_0196 | Pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.800 |
CC_1727 | leuD | CC_1727 | CC_0195 | Pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.827 |
CC_2100 | CC_1727 | CC_2100 | CC_1727 | Acetolactate synthase, large subunit; Identified by match to TIGR protein family HMM TIGR00118. | Pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.849 |
CC_2100 | CC_2622 | CC_2100 | CC_2622 | Acetolactate synthase, large subunit; Identified by match to TIGR protein family HMM TIGR00118. | NADP-dependent malic enzyme; Identified by match to PFAM protein family HMM PF01515. | 0.911 |
CC_2100 | IlvH | CC_2100 | CC_2101 | Acetolactate synthase, large subunit; Identified by match to TIGR protein family HMM TIGR00118. | Acetolactate synthase, small subunit; Identified by match to TIGR protein family HMM TIGR00119. | 0.999 |
CC_2100 | ilvC | CC_2100 | CC_2120 | Acetolactate synthase, large subunit; Identified by match to TIGR protein family HMM TIGR00118. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.993 |
CC_2100 | ilvE | CC_2100 | CC_2929 | Acetolactate synthase, large subunit; Identified by match to TIGR protein family HMM TIGR00118. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.646 |
CC_2100 | leuA | CC_2100 | CC_1541 | Acetolactate synthase, large subunit; Identified by match to TIGR protein family HMM TIGR00118. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.966 |
CC_2100 | leuB | CC_2100 | CC_0193 | Acetolactate synthase, large subunit; Identified by match to TIGR protein family HMM TIGR00118. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.989 |
CC_2100 | leuC | CC_2100 | CC_0196 | Acetolactate synthase, large subunit; Identified by match to TIGR protein family HMM TIGR00118. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.775 |
CC_2100 | leuD | CC_2100 | CC_0195 | Acetolactate synthase, large subunit; Identified by match to TIGR protein family HMM TIGR00118. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.839 |
CC_2622 | CC_1727 | CC_2622 | CC_1727 | NADP-dependent malic enzyme; Identified by match to PFAM protein family HMM PF01515. | Pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.969 |
CC_2622 | CC_2100 | CC_2622 | CC_2100 | NADP-dependent malic enzyme; Identified by match to PFAM protein family HMM PF01515. | Acetolactate synthase, large subunit; Identified by match to TIGR protein family HMM TIGR00118. | 0.911 |