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msbA msbA lpxK lpxK lolD lolD Sde_1291 Sde_1291 Sde_3725 Sde_3725 Sde_0386 Sde_0386 dnaK dnaK Sde_0688 Sde_0688 ilvE ilvE Sde_0689 Sde_0689 rsmA rsmA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
msbALipid A export ATP-binding/permease protein MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. (586 aa)    
Predicted Functional Partners:
lpxK
lipid-A-disaccharide synthase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
  
 0.950
lolD
Lipoprotein releasing system, ATP-binding protein; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
    
0.918
Sde_1291
ABC transporter related.
 
 
 
0.785
Sde_3725
Amino acid adenylation.
  
 0.712
Sde_0386
Putative CMP-KDO KDO transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family.
 
   
 0.711
dnaK
Chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 0.663
Sde_0688
Beta-ketoacyl synthase.
  
 0.595
ilvE
Branched chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
     
 0.567
Sde_0689
Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase, FabA/FabZ; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
  
 
 0.538
rsmA
Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
  
     0.520
Your Current Organism:
Saccharophagus degradans
NCBI taxonomy Id: 203122
Other names: Microbulbifer degradans 2-40, Microbulbifer sp. 2-40, S. degradans 2-40, Saccharophagus degradans 2-40, Saccharophagus degradans ATCC 43961, Saccharophagus degradans str. 2-40, Saccharophagus degradans strain 2-40, bacterium 2-40
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