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pyrE pyrE pyrF pyrF pyrD pyrD prs prs ascD ascD b0033 b0033 fadI fadI pyrB pyrB b0032 b0032 YPO0034 YPO0034 phnN phnN
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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[Homology]
Score
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (215 aa)    
Predicted Functional Partners:
pyrF
Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
  
 
 0.998
pyrD
Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
  
 0.997
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
  
 
 0.978
ascD
Cdp-6-deoxy-delta-3,4-glucoseen reductase; Participates in the conversion of CDP-6-deoxy-D-glycero-L- threo-4-hexulose to 3,6-dideoxy-D-glycero-D-glycero-4-hexulose together with CDP-6-deoxy-D-glycero-L-threo-4-hexulose-3-dehydrase (E1) in two consecutive steps. The detailed mechanism of E3 is not yet resolved (By similarity).
  
 
 0.930
b0033
Similar to Escherichia coli carbamoyl-phosphate synthase large chain CarB SW:CARB_ECOLI (P00968) (1072 aa) fasta scores: E(): 0, 92.6% id in 1072 aa, and to Salmonella typhimurium carbamoyl-phosphate synthase large chain CarB SW:CARB_SALTY (P14846) (1074 aa) fasta scores: E(): 0, 92.7% id in 1072 aa.
  
 
 0.924
fadI
Similar to Escherichia coli NAD(P)H-flavin reductase Fre or FlrD or FadI or FsrC or UbiB SW:FRE_ECOLI (P23486) (232 aa) fasta scores: E(): 0, 77.6% id in 232 aa, and to Salmonella typhimurium LT2 UbiB protein TR:Q9L6L9 (EMBL:AF233324) (233 aa) fasta scores: E(): 0, 79.4% id in 233 aa.
  
 
 0.916
pyrB
Similar to Escherichia coli aspartate carbamoyltransferase catalytic chain PyrB SW:PYRB_ECOLI (P00479) (310 aa) fasta scores: E(): 0, 84.8% id in 310 aa,and to Erwinia herbicola aspartate transcarbamylase catalytic subunit PyrB TR:Q9RMS8 (EMBL:AF190426) (311 aa) fasta scores: E(): 0, 85.9% id in 311 aa.
  
  
 0.911
b0032
Similar to Escherichia coli carbamoyl-phosphate synthase small chain CarA SW:CARA_ECOLI (P00907) (382 aa) fasta scores: E(): 0, 86.4% id in 381 aa, and to Salmonella typhimurium carbamoyl-phosphate synthase small chain CarA SW:CARA_SALTY (P14845) (382 aa) fasta scores: E(): 0, 86.4% id in 381 aa; Belongs to the CarA family.
  
  
 0.904
YPO0034
Similar to Escherichia coli putative purine permease YicE SW:YICE_ECOLI (P27432) (463 aa) fasta scores: E(): 0,84.0% id in 462 aa and to Vibrio cholerae xanthine/uracil permease family protein vc2712 TR:Q9KNM0 (EMBL:AE004337) (480 aa) fasta scores: E(): 0, 69.1% id in 450 aa.
  
  
 0.892
phnN
PhnN protein; Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP).
     
  0.882
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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