STRINGSTRING
folE folE folK folK ribA ribA dhpS dhpS folB folB ygcM ygcM ndk ndk ntpA ntpA bisA bisA pykA pykA pykF pykF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
folESimilar to Escherichia coli GTP cyclohydrolase I SW:GCH1_ECOLI (P27511) (221 aa) fasta scores: E(): 0, 90.0% id in 219 aa, and to Vibrio cholerae GTP cyclohydrolase Vca0616 TR:Q9KLX5 (EMBL:AE004391) (230 aa) fasta scores: E(): 0, 70.2% id in 218 aa. (220 aa)    
Predicted Functional Partners:
folK
Similar to Escherichia coli 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FolK SW:HPPK_ECOLI (P26281) (158 aa) fasta scores: E(): 0, 63.2% id in 155 aa, and to Vibrio cholerae 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Vc0593 TR:Q9KUC9 (EMBL:AE004144) (167 aa) fasta scores: E(): 0, 59.7% id in 159 aa.
  
 0.993
ribA
GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
 
 
 
 0.987
dhpS
Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
 
 
 0.981
folB
Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
 
 
 0.973
ygcM
Similar to Escherichia coli putative 6-pyruvoyl tetrahydrobiopterin synthase YgcM SW:PTPS_ECOLI (Q46903) (121 aa) fasta scores: E(): 0, 83.2% id in 119 aa, and to Vibrio cholerae putative 6-pyruvoyl tetrahydrobiopterin synthase Vc1299 TR:Q9KSF7 (EMBL:AE004209) (122 aa) fasta scores: E(): 0, 76.5% id in 119 aa.
  
 
 0.965
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
   
 0.948
ntpA
Similar to Escherichia coli dATP pyrophosphohydrolase NudB SW:NUDB_ECOLI (P24236) (150 aa) fasta scores: E(): 0, 73.9% id in 142 aa, and to Haemophilus influenzae dATP pyrophosphohydrolase NudB SW:NUDB_HAEIN (P44635) (158 aa) fasta scores: E(): 2.6e-29,52.1% id in 144 aa.
  
 
  0.941
bisA
Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.
    
  0.940
pykA
Pyruvate kinase II; Similar to Escherichia coli pyruvate kinase II PykA SW:KPY2_ECOLI (P21599) (479 aa) fasta scores: E(): 0, 89.6% id in 479 aa, and to Haemophilus influenzae pyruvate kinase PykA SW:KPYK_HAEIN (P43924) (477 aa) fasta scores: E(): 0,75.4% id in 479 aa.
    
  0.937
pykF
Pyruvate kinase I; Similar to Escherichia coli pyruvate kinase I PykF SW:KPY1_ECOLI (P14178) (470 aa) fasta scores: E(): 0, 86.6% id in 470 aa, and to Salmonella typhimurium pyruvate kinase I PykF SW:KPY1_SALTY (P77983) (470 aa) fasta scores: E(): 0, 86.6% id in 470 aa.
    
  0.937
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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