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trpD trpD trpC trpC trpG trpG trpE trpE pabA pabA irp9 irp9 trpB trpB trpA trpA pabB pabB YPO1976 YPO1976 menF menF
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (333 aa)    
Predicted Functional Partners:
trpC
Tryptophan biosynthesis protein TrpCF; Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity).
 
 0.999
trpG
Anthranilate synthase component II; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...]
 
 0.999
trpE
Similar to Escherichia coli anthranilate synthase component I TrpE SW:TRPE_ECOLI (P00895) (520 aa) fasta scores: E(): 0, 76.0% id in 520 aa, and to Salmonella typhimurium anthranilate synthase component I TrpE SW:TRPE_SALTY (P00898) (520 aa) fasta scores: E(): 0, 74.4% id in 520 aa.
 
 0.999
pabA
Similar to para-aminobenzoate synthase glutamine amidotransferase components II from several including: Serratia marcescens SW:PABA_SERMA (P06195) (191 aa) fasta scores: E(): 0, 84.7% id in 189 aa and to Escherichia coli SW:PABA_ECOLI (P00903) (187 aa) fasta scores: E(): 0, 74.1% id in 189 aa.
 
 0.997
irp9
Previously sequenced as Yersinia pestis putative salicylate synthetase YbtS TR:Q9Z396 (EMBL:AL031866) (434 aa) fasta scores: E(): 0, 100.0% id in 434 aa. Similar to Yersinia enterocolitica salicylate synthetase Irp9 TR:Q9X9I8 (EMBL:AJ132668) (434 aa) fasta scores: E(): 0,99.3% id in 434 aa.
 
 0.993
trpB
Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
 
 
 0.992
trpA
Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 
  
 0.989
pabB
Similar to Salmonella typhimurium para-aminobenzoate synthase component I PabB SW:PABB_SALTY (P12680) (454 aa) fasta scores: E(): 0, 67.6% id in 447 aa, and to Escherichia coli para-aminobenzoate synthase component I PabB SW:PABB_ECOLI (P05041) (453 aa) fasta scores: E(): 0,66.7% id in 447 aa.
 
 0.987
YPO1976
Hypothetical protein; Previously sequenced as Yersinia pestis hypothetical protein TR:Q9ZC78 (EMBL:AL031866) (658 aa) fasta scores: E(): 0, 100.0% id in 658 aa. The C-terminal region of this CDS shows also some similarity to the C-terminal region of salicylate synthetase component I from Yersinia enterocolitica Irp9 [TR:Q9X9I8 (EMBL:AJ132668) (434 aa) fasta scores: E(): 5.8e-25, 35.5% id in 262 aa] and from a wide range of other microorganisms. Contains a 5x YT repeat codons 22..31.
 
 0.972
menF
Menaquinone-specific isochorismate synthase; Catalyzes the conversion of chorismate to isochorismate.
  
 
 0.812
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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