STRINGSTRING
lpp lpp lolA lolA tonB tonB bglY bglY con con YPO3918 YPO3918 lolC lolC ymoA ymoA ompC ompC yajG yajG YPO2199 YPO2199
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
lppMajor outer membrane lipoprotein; A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane. (78 aa)    
Predicted Functional Partners:
lolA
Putative outer-membrane lipoproteins carrier protein; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
  
 
 
 0.930
tonB
TonB protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family.
    
   0.880
bglY
DNA-binding protein Hns; Similar to Escherichia coli histone-like DNA-binding protein Hns SW:HNS_ECOLI (P08936) (136 aa) fasta scores: E(): 0, 84.3% id in 134 aa, and to Similar to Serratia marcescens DNA-binding protein Hns SW:HNS_SERMA (P18955) (134 aa) fasta scores: E(): 0, 92.5% id in 134 aa; Belongs to the histone-like protein H-NS family.
  
    0.823
con
Putative outer membrane porin A protein; With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage.
 
 
 0.814
YPO3918
Putative membrane protein; Similar to Pseudomonas putida ferric-siderophore transport protein TonB SW:TONB_PSEPU (Q05613) (243 aa) fasta scores: E(): 1.5e-13, 32.0% id in 253 aa, and to Haemophilus influenzae energy transducer protein TonB SW:TONB_HAEIN (P42872) (270 aa) fasta scores: E(): 1.3e-08,27.5% id in 280 aa.
    
   0.808
lolC
Similar to Escherichia coli lipoprotein releasing system transmembrane protein LolC SW:LOLC_ECOLI (P75956) (399 aa) fasta scores: E(): 0, 78.5% id in 400 aa, and to Vibrio cholerae hypothetical protein Vc1884 TR:Q9KQW4 (EMBL:AE004263) (406 aa) fasta scores: E(): 0, 53.2% id in 402 aa.
  
 
 
 0.769
ymoA
Modulating protein YmoA (histone-like protein); Modulates the thermoregulation of VirF, and hence the yop regulon, as well as the expression of the enterotoxin gene yst. Involved in chromosome structure and DNA topology; probably by means of compaction of DNA in conjunction with H-NS; probably requires H-NS to bind DNA (By similarity); Belongs to the Hha/YmoA/Cnu family.
  
    0.761
ompC
Similar to Escherichia coli outer membrane protein C precursor OmpC or MeoA or Par SW:OMPC_ECOLI (P06996) (367 aa) fasta scores: E(): 0, 70.3% id in 381 aa, and to Serratia marcescens outer membrane protein C precursor OmpC SW:OMPC_SERMA (Q54471) (376 aa) fasta scores: E(): 0, 68.1% id in 382 aa; Belongs to the Gram-negative porin family.
  
  
 0.759
yajG
Putative lipoprotein; Similar to Escherichia coli hypothetical 20.9 kDa lipoprotein in ampG-bolA intergenic region precursor YajG SW:YAJG_ECOLI (P36671) (192 aa) fasta scores: E(): 0, 72.4% id in 192 aa.
  
     0.759
YPO2199
Putative sulfate transporter (pseudogene); Pfam match to entry PF01740 STAS, STAS domain, score 42.50, E-value 9.5e-09.
  
     0.758
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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