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dctP dctP dctS dctS dctB dctB dctR dctR rbsD rbsD rbsA rbsA fbpC fbpC rbsR rbsR rbsB rbsB rbsK rbsK rbsC rbsC
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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dctPC4-dicarboxylate transport protein; Responsible for the transport of succinate and fumarate, but not malate, across the membrane. (421 aa)    
Predicted Functional Partners:
dctS
Two-component sensor histidine kinase; Member of the two-component regulatory system DctS/DctR. Probably activates DctR by phosphorylation (By similarity). Essential for expression of dctP.
 
  
 0.951
dctB
C4-dicarboxylate binding protein; Part of the binding-protein-dependent transport system for uptake of C4-dicarboxylates. Responsible for growth on fumarate and succinate but not malate. Is not directly involved in C4-dicarboxylate uptake, but plays a sensory role in the DctS/DctR two-component system which regulates the expression of the dctA C4-dicarboxylate transporter; Belongs to the bacterial solute-binding protein 7 family.
  
  
 0.916
dctR
Two-component response regulator; Member of the two-component regulatory system DctS/DctR. Essential for expression of dctP.
  
  
 0.769
rbsD
Ribose ABC transporter (membrane bound ribose binding); Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
   
  
 0.695
rbsA
Ribose ABC transporter (ATP-binding protein); Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family.
   
  
 0.648
fbpC
Regulator of iron homeostasis; Evidence 1a: Function experimentally demonstrated in the studied strain; Product type r: regulator.
      
 0.632
rbsR
Transcriptional regulator (LacI family); Transcriptional repressor for the ribose rbsDACBK operon.
   
    0.620
rbsB
Ribose ABC transporter (ribose-binding lipoprotein); Part of the ABC transporter complex RbsABC involved in ribose import. Binds ribose.
   
    0.554
rbsK
Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
   
   0.537
rbsC
Ribose ABC transporter (permease); Part of the ABC transporter complex RbsABC involved in ribose import. Probably responsible for the translocation of the substrate across the membrane.
   
    0.525
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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