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glyA glyA lpd lpd thyA thyA folA folA pssA pssA folC folC nadE nadE groES groES adk adk sua5 sua5 pyrH pyrH
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (416 aa)    
Predicted Functional Partners:
lpd
Fatty acid/phospholipid biosynthesis enzyme; Identified by sequence similarity; putative.
  
 0.980
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.976
folA
Dihydrofolate reductase; Identified by sequence similarity; putative; Belongs to the dihydrofolate reductase family.
  
 
 0.969
pssA
Phosphatidylserine synthase; Identified by sequence similarity; putative.
    
 0.927
folC
Folylpolyglutamate synthase; Identified by sequence similarity; putative; Belongs to the folylpolyglutamate synthase family.
  
 0.918
nadE
NAD synthase; Identified by sequence similarity; putative.
  
 
 0.904
groES
Chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter; Belongs to the GroES chaperonin family.
   
 0.887
adk
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
  
 
 0.873
sua5
Translation factor; Identified by sequence similarity; putative; Belongs to the SUA5 family.
    
 0.868
pyrH
Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.
  
 
 0.860
Your Current Organism:
Onion yellows
NCBI taxonomy Id: 262768
Other names: O. yellows phytoplasma OY-M, Onion yellows phytoplasma OY-M
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