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trpF trpF trpC trpC trpD trpD trpA trpA trpB1 trpB1 ribA ribA trpR trpR kprS kprS kynU kynU aroE aroE trpB3 trpB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
trpFN- (5'-phosphoribosyl) anthranilate isomerase; EC 5.3.1.24; Belongs to the TrpF family. (206 aa)    
Predicted Functional Partners:
trpC
Indole-3-glycerol phosphate synthase; EC 4.1.1.48.
 
 0.999
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
 
 0.999
trpA
Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 
  
 0.990
trpB1
Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
 
  
 0.985
ribA
Riboflavin biosynthesis protein; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
     
 0.961
trpR
Transcription factor/trp operon repressor; This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription.
     
 0.908
kprS
Ribose-phosphate pyrophosphokinase; EC 2.7.6.1.
     
 0.824
kynU
Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively.
       0.805
aroE
Shikimate biosynthesis protein subunit.
     
 0.726
trpB3
Tryptophan synthase beta chain; EC 4.2.1.20.
  
  
 0.713
Your Current Organism:
Chlamydia felis
NCBI taxonomy Id: 264202
Other names: C. felis Fe/C-56, Chlamydia felis Fe/C-56, Chlamydophila felis Fe/C-56
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