STRINGSTRING
APE_0148.1 APE_0148.1 rtcB rtcB prf1 prf1 rtcA rtcA nth nth APE_0151.1 APE_0151.1 orc2 orc2 APE_2062.1 APE_2062.1 APE_0781.1 APE_0781.1 APE_0152a APE_0152a
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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APE_0148.1Conserved hypothetical protein; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity). (144 aa)    
Predicted Functional Partners:
rtcB
Conserved hypothetical protein; GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends; Belongs to the RtcB family.
 
 0.948
prf1
Peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Belongs to the eukaryotic release factor 1 family.
  
    0.778
rtcA
RNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
 
 
 
 0.648
nth
Endonuclease III; DNA-(apurinic or apyrimidinic site) lyase.
       0.557
APE_0151.1
Hypothetical protein.
       0.554
orc2
Origin recognition complex subunit 2 Orc2; Involved in regulation of DNA replication (By similarity). Binds DNA; Belongs to the CDC6/cdc18 family.
       0.447
APE_2062.1
Ribonucleotide reductase, B12-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
   
    0.418
APE_0781.1
Conserved hypothetical protein; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family.
  
     0.413
APE_0152a
Hypothetical protein.
       0.404
Your Current Organism:
Aeropyrum pernix
NCBI taxonomy Id: 272557
Other names: A. pernix K1, Aeropyrum pernix K1, Aeropyrum pernix str. K1, Aeropyrum pernix strain K1
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