node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APE_0152a | orc2 | APE_0152a | APE_0152.1 | Hypothetical protein. | Origin recognition complex subunit 2 Orc2; Involved in regulation of DNA replication (By similarity). Binds DNA; Belongs to the CDC6/cdc18 family. | 0.771 |
APE_0188.1 | APE_1323.1 | APE_0188.1 | APE_1323.1 | Minichromosome maintenance protein; DNA replication licensing factor; MCM; Belongs to the MCM family. | Single-stranded DNA binding protein; SSB. | 0.948 |
APE_0188.1 | fen | APE_0188.1 | APE_0115.1 | Minichromosome maintenance protein; DNA replication licensing factor; MCM; Belongs to the MCM family. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.895 |
APE_0188.1 | orc1 | APE_0188.1 | APE_0475.1 | Minichromosome maintenance protein; DNA replication licensing factor; MCM; Belongs to the MCM family. | Origin recognition complex subunit 1 Orc1; Involved in regulation of DNA replication (By similarity). Binds DNA; Belongs to the CDC6/cdc18 family. | 0.983 |
APE_0188.1 | orc2 | APE_0188.1 | APE_0152.1 | Minichromosome maintenance protein; DNA replication licensing factor; MCM; Belongs to the MCM family. | Origin recognition complex subunit 2 Orc2; Involved in regulation of DNA replication (By similarity). Binds DNA; Belongs to the CDC6/cdc18 family. | 0.982 |
APE_0188.1 | polA | APE_0188.1 | APE_0099 | Minichromosome maintenance protein; DNA replication licensing factor; MCM; Belongs to the MCM family. | Family B DNA polymerase I. | 0.953 |
APE_0188.1 | priA | APE_0188.1 | APE_0438.1 | Minichromosome maintenance protein; DNA replication licensing factor; MCM; Belongs to the MCM family. | DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] | 0.946 |
APE_0188.1 | priB | APE_0188.1 | APE_0667 | Minichromosome maintenance protein; DNA replication licensing factor; MCM; Belongs to the MCM family. | DNA primase 46 kDa subunit; p46. | 0.960 |
APE_0188.1 | tfb-2 | APE_0188.1 | APE_2443.1 | Minichromosome maintenance protein; DNA replication licensing factor; MCM; Belongs to the MCM family. | Transcription initiation factor IIB; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). | 0.471 |
APE_1323.1 | APE_0188.1 | APE_1323.1 | APE_0188.1 | Single-stranded DNA binding protein; SSB. | Minichromosome maintenance protein; DNA replication licensing factor; MCM; Belongs to the MCM family. | 0.948 |
APE_1323.1 | dnaG | APE_1323.1 | APE_2096.1 | Single-stranded DNA binding protein; SSB. | Exosome complex RNA helicase DnaG homologue; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | 0.504 |
APE_1323.1 | fen | APE_1323.1 | APE_0115.1 | Single-stranded DNA binding protein; SSB. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.785 |
APE_1323.1 | orc1 | APE_1323.1 | APE_0475.1 | Single-stranded DNA binding protein; SSB. | Origin recognition complex subunit 1 Orc1; Involved in regulation of DNA replication (By similarity). Binds DNA; Belongs to the CDC6/cdc18 family. | 0.810 |
APE_1323.1 | orc2 | APE_1323.1 | APE_0152.1 | Single-stranded DNA binding protein; SSB. | Origin recognition complex subunit 2 Orc2; Involved in regulation of DNA replication (By similarity). Binds DNA; Belongs to the CDC6/cdc18 family. | 0.795 |
APE_1323.1 | polA | APE_1323.1 | APE_0099 | Single-stranded DNA binding protein; SSB. | Family B DNA polymerase I. | 0.743 |
APE_1323.1 | priA | APE_1323.1 | APE_0438.1 | Single-stranded DNA binding protein; SSB. | DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] | 0.878 |
APE_1323.1 | priB | APE_1323.1 | APE_0667 | Single-stranded DNA binding protein; SSB. | DNA primase 46 kDa subunit; p46. | 0.831 |
dnaG | APE_1323.1 | APE_2096.1 | APE_1323.1 | Exosome complex RNA helicase DnaG homologue; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | Single-stranded DNA binding protein; SSB. | 0.504 |
dnaG | fen | APE_2096.1 | APE_0115.1 | Exosome complex RNA helicase DnaG homologue; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.751 |
dnaG | orc1 | APE_2096.1 | APE_0475.1 | Exosome complex RNA helicase DnaG homologue; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | Origin recognition complex subunit 1 Orc1; Involved in regulation of DNA replication (By similarity). Binds DNA; Belongs to the CDC6/cdc18 family. | 0.731 |