node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APE_0330.1 | dut-2 | APE_0330.1 | APE_0333.1 | Conserved hypothetical protein. | dUTP diphosphatase; Catalyzes the deamination of dCTP to dUTP. | 0.517 |
APE_0330.1 | guaA | APE_0330.1 | APE_2452 | Conserved hypothetical protein. | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.540 |
dut | dut-2 | APE_0069.1 | APE_0333.1 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | dUTP diphosphatase; Catalyzes the deamination of dCTP to dUTP. | 0.945 |
dut | guaA | APE_0069.1 | APE_2452 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.444 |
dut | ndk | APE_0069.1 | APE_2377 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | 0.933 |
dut | pyrE | APE_0069.1 | APE_2349.1 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.490 |
dut | rfbD | APE_0069.1 | APE_1179.1 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | dTDP-4-dehydrorhamnose reductase; RmlD. | 0.647 |
dut | thyX | APE_0069.1 | APE_2064.1 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.931 |
dut-2 | APE_0330.1 | APE_0333.1 | APE_0330.1 | dUTP diphosphatase; Catalyzes the deamination of dCTP to dUTP. | Conserved hypothetical protein. | 0.517 |
dut-2 | dut | APE_0333.1 | APE_0069.1 | dUTP diphosphatase; Catalyzes the deamination of dCTP to dUTP. | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.945 |
dut-2 | guaA | APE_0333.1 | APE_2452 | dUTP diphosphatase; Catalyzes the deamination of dCTP to dUTP. | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.444 |
dut-2 | ndk | APE_0333.1 | APE_2377 | dUTP diphosphatase; Catalyzes the deamination of dCTP to dUTP. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | 0.933 |
dut-2 | pyrE | APE_0333.1 | APE_2349.1 | dUTP diphosphatase; Catalyzes the deamination of dCTP to dUTP. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.490 |
dut-2 | pyrG | APE_0333.1 | APE_1604 | dUTP diphosphatase; Catalyzes the deamination of dCTP to dUTP. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.929 |
dut-2 | rfbD | APE_0333.1 | APE_1179.1 | dUTP diphosphatase; Catalyzes the deamination of dCTP to dUTP. | dTDP-4-dehydrorhamnose reductase; RmlD. | 0.647 |
dut-2 | thyX | APE_0333.1 | APE_2064.1 | dUTP diphosphatase; Catalyzes the deamination of dCTP to dUTP. | Thymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.504 |
guaA | APE_0330.1 | APE_2452 | APE_0330.1 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Conserved hypothetical protein. | 0.540 |
guaA | dut | APE_2452 | APE_0069.1 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.444 |
guaA | dut-2 | APE_2452 | APE_0333.1 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | dUTP diphosphatase; Catalyzes the deamination of dCTP to dUTP. | 0.444 |
guaA | ndk | APE_2452 | APE_2377 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | 0.721 |