node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APE_1106.1 | ppnK | APE_1106.1 | APE_1104.1 | Conserved hypothetical protein. | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.673 |
APE_1106.1 | vapC3 | APE_1106.1 | APE_1102 | Conserved hypothetical protein. | Conserved hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. An RNase; Belongs to the PINc/VapC protein family. | 0.747 |
APE_1273.1 | nadE | APE_1273.1 | APE_1958.1 | Conserved hypothetical protein. | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.829 |
APE_1273.1 | nadM | APE_1273.1 | APE_0513.1 | Conserved hypothetical protein. | NMN adenylyltransferase. | 0.931 |
APE_1273.1 | nadM-2 | APE_1273.1 | APE_1986.1 | Conserved hypothetical protein. | NMN adenylyltransferase; Belongs to the archaeal NMN adenylyltransferase family. | 0.931 |
APE_1273.1 | npdA | APE_1273.1 | APE_1782.1 | Conserved hypothetical protein. | NAD-dependent deacetylase; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily. | 0.558 |
APE_1273.1 | ppnK | APE_1273.1 | APE_1104.1 | Conserved hypothetical protein. | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.596 |
APE_1273.1 | surE | APE_1273.1 | APE_0801.1 | Conserved hypothetical protein. | 5'(3')-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.908 |
fgs | ppnK | APE_1764.1 | APE_1104.1 | Farnesylgeranyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.581 |
nadE | APE_1273.1 | APE_1958.1 | APE_1273.1 | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | Conserved hypothetical protein. | 0.829 |
nadE | nadM | APE_1958.1 | APE_0513.1 | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | NMN adenylyltransferase. | 0.948 |
nadE | nadM-2 | APE_1958.1 | APE_1986.1 | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | NMN adenylyltransferase; Belongs to the archaeal NMN adenylyltransferase family. | 0.946 |
nadE | npdA | APE_1958.1 | APE_1782.1 | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | NAD-dependent deacetylase; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily. | 0.941 |
nadE | ppnK | APE_1958.1 | APE_1104.1 | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.957 |
nadM | APE_1273.1 | APE_0513.1 | APE_1273.1 | NMN adenylyltransferase. | Conserved hypothetical protein. | 0.931 |
nadM | nadE | APE_0513.1 | APE_1958.1 | NMN adenylyltransferase. | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.948 |
nadM | nadM-2 | APE_0513.1 | APE_1986.1 | NMN adenylyltransferase. | NMN adenylyltransferase; Belongs to the archaeal NMN adenylyltransferase family. | 0.907 |
nadM | npdA | APE_0513.1 | APE_1782.1 | NMN adenylyltransferase. | NAD-dependent deacetylase; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily. | 0.963 |
nadM | ppnK | APE_0513.1 | APE_1104.1 | NMN adenylyltransferase. | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.916 |
nadM | surE | APE_0513.1 | APE_0801.1 | NMN adenylyltransferase. | 5'(3')-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |