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ppnK ppnK nadE nadE npdA npdA nadM nadM nadM-2 nadM-2 vapC3 vapC3 APE_1106.1 APE_1106.1 srp54 srp54 APE_1273.1 APE_1273.1 fgs fgs surE surE
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ppnKInorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (280 aa)    
Predicted Functional Partners:
nadE
NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
    
 0.957
npdA
NAD-dependent deacetylase; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily.
  
 
 0.935
nadM
NMN adenylyltransferase.
    
 0.916
nadM-2
NMN adenylyltransferase; Belongs to the archaeal NMN adenylyltransferase family.
    
 0.916
vapC3
Conserved hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. An RNase; Belongs to the PINc/VapC protein family.
       0.839
APE_1106.1
Conserved hypothetical protein.
       0.673
srp54
Signal recognition 54 kDa protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily.
 
    0.648
APE_1273.1
Conserved hypothetical protein.
     
 0.596
fgs
Farnesylgeranyl diphosphate synthase; Belongs to the FPP/GGPP synthase family.
 
 
 
 0.581
surE
5'(3')-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
 
   
 0.570
Your Current Organism:
Aeropyrum pernix
NCBI taxonomy Id: 272557
Other names: A. pernix K1, Aeropyrum pernix K1, Aeropyrum pernix str. K1, Aeropyrum pernix strain K1
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