node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BPSS0305 | ilvC | BPSS0305 | BPSL1198 | Similar to Bacillus subtilis ketol-acid reductoisomerase IlvC SWALL:ILVC_BACSU (SWALL:P37253) (342 aa) fasta scores: E(): 7e-27, 36.91% id in 298 aa, and to Neisseria meningitidis ketol-acid reductoisomerase nma1763 SWALL:ILVC_NEIMA (SWALL:Q9JTI3) (337 aa) fasta scores: E(): 9.9e-31, 35.71% id in 322 aa. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.921 |
BPSS0305 | ilvD | BPSS0305 | BPSL0969 | Similar to Bacillus subtilis ketol-acid reductoisomerase IlvC SWALL:ILVC_BACSU (SWALL:P37253) (342 aa) fasta scores: E(): 7e-27, 36.91% id in 298 aa, and to Neisseria meningitidis ketol-acid reductoisomerase nma1763 SWALL:ILVC_NEIMA (SWALL:Q9JTI3) (337 aa) fasta scores: E(): 9.9e-31, 35.71% id in 322 aa. | Similar to Lactococcus lactis dihydroxy-acid dehydratase IlvD or ll1223 SWALL:ILVD_LACLA (SWALL:Q02139) (570 aa) fasta scores: E(): 4.6e-100, 49.63% id in 554 aa, and to Ralstonia solanacearum dihydroxy-acid dehydratase IlvD or rsc2412 or rs02706 SWALL:ILVD_RALSO (SWALL:Q8XWR1) (557 aa) fasta scores: E(): 1.2e-186, 86.33% id in 556 aa; Belongs to the IlvD/Edd family. | 0.992 |
BPSS0305 | ilvE | BPSS0305 | BPSL0793 | Similar to Bacillus subtilis ketol-acid reductoisomerase IlvC SWALL:ILVC_BACSU (SWALL:P37253) (342 aa) fasta scores: E(): 7e-27, 36.91% id in 298 aa, and to Neisseria meningitidis ketol-acid reductoisomerase nma1763 SWALL:ILVC_NEIMA (SWALL:Q9JTI3) (337 aa) fasta scores: E(): 9.9e-31, 35.71% id in 322 aa. | Putative branched-chain amino acid aminotransferase IlvE; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.413 |
BPSS0305 | ilvE-2 | BPSS0305 | BPSS1810 | Similar to Bacillus subtilis ketol-acid reductoisomerase IlvC SWALL:ILVC_BACSU (SWALL:P37253) (342 aa) fasta scores: E(): 7e-27, 36.91% id in 298 aa, and to Neisseria meningitidis ketol-acid reductoisomerase nma1763 SWALL:ILVC_NEIMA (SWALL:Q9JTI3) (337 aa) fasta scores: E(): 9.9e-31, 35.71% id in 322 aa. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.486 |
BPSS0305 | leuA | BPSS0305 | BPSL1201 | Similar to Bacillus subtilis ketol-acid reductoisomerase IlvC SWALL:ILVC_BACSU (SWALL:P37253) (342 aa) fasta scores: E(): 7e-27, 36.91% id in 298 aa, and to Neisseria meningitidis ketol-acid reductoisomerase nma1763 SWALL:ILVC_NEIMA (SWALL:Q9JTI3) (337 aa) fasta scores: E(): 9.9e-31, 35.71% id in 322 aa. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.882 |
BPSS0305 | leuA-2 | BPSS0305 | BPSL0507 | Similar to Bacillus subtilis ketol-acid reductoisomerase IlvC SWALL:ILVC_BACSU (SWALL:P37253) (342 aa) fasta scores: E(): 7e-27, 36.91% id in 298 aa, and to Neisseria meningitidis ketol-acid reductoisomerase nma1763 SWALL:ILVC_NEIMA (SWALL:Q9JTI3) (337 aa) fasta scores: E(): 9.9e-31, 35.71% id in 322 aa. | hydroxymethylglutaryl-CoA lyase-like protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.783 |
BPSS0305 | leuB | BPSS0305 | BPSS1705 | Similar to Bacillus subtilis ketol-acid reductoisomerase IlvC SWALL:ILVC_BACSU (SWALL:P37253) (342 aa) fasta scores: E(): 7e-27, 36.91% id in 298 aa, and to Neisseria meningitidis ketol-acid reductoisomerase nma1763 SWALL:ILVC_NEIMA (SWALL:Q9JTI3) (337 aa) fasta scores: E(): 9.9e-31, 35.71% id in 322 aa. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.923 |
BPSS0305 | leuC | BPSS0305 | BPSS1707 | Similar to Bacillus subtilis ketol-acid reductoisomerase IlvC SWALL:ILVC_BACSU (SWALL:P37253) (342 aa) fasta scores: E(): 7e-27, 36.91% id in 298 aa, and to Neisseria meningitidis ketol-acid reductoisomerase nma1763 SWALL:ILVC_NEIMA (SWALL:Q9JTI3) (337 aa) fasta scores: E(): 9.9e-31, 35.71% id in 322 aa. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.948 |
BPSS0305 | leuD | BPSS0305 | BPSS1706 | Similar to Bacillus subtilis ketol-acid reductoisomerase IlvC SWALL:ILVC_BACSU (SWALL:P37253) (342 aa) fasta scores: E(): 7e-27, 36.91% id in 298 aa, and to Neisseria meningitidis ketol-acid reductoisomerase nma1763 SWALL:ILVC_NEIMA (SWALL:Q9JTI3) (337 aa) fasta scores: E(): 9.9e-31, 35.71% id in 322 aa. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.943 |
ilvC | BPSS0305 | BPSL1198 | BPSS0305 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Similar to Bacillus subtilis ketol-acid reductoisomerase IlvC SWALL:ILVC_BACSU (SWALL:P37253) (342 aa) fasta scores: E(): 7e-27, 36.91% id in 298 aa, and to Neisseria meningitidis ketol-acid reductoisomerase nma1763 SWALL:ILVC_NEIMA (SWALL:Q9JTI3) (337 aa) fasta scores: E(): 9.9e-31, 35.71% id in 322 aa. | 0.921 |
ilvC | ilvD | BPSL1198 | BPSL0969 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Similar to Lactococcus lactis dihydroxy-acid dehydratase IlvD or ll1223 SWALL:ILVD_LACLA (SWALL:Q02139) (570 aa) fasta scores: E(): 4.6e-100, 49.63% id in 554 aa, and to Ralstonia solanacearum dihydroxy-acid dehydratase IlvD or rsc2412 or rs02706 SWALL:ILVD_RALSO (SWALL:Q8XWR1) (557 aa) fasta scores: E(): 1.2e-186, 86.33% id in 556 aa; Belongs to the IlvD/Edd family. | 0.995 |
ilvC | ilvE | BPSL1198 | BPSL0793 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Putative branched-chain amino acid aminotransferase IlvE; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.494 |
ilvC | ilvE-2 | BPSL1198 | BPSS1810 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.487 |
ilvC | leuA | BPSL1198 | BPSL1201 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.886 |
ilvC | leuA-2 | BPSL1198 | BPSL0507 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | hydroxymethylglutaryl-CoA lyase-like protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.788 |
ilvC | leuB | BPSL1198 | BPSS1705 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.914 |
ilvC | leuC | BPSL1198 | BPSS1707 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.932 |
ilvC | leuD | BPSL1198 | BPSS1706 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.931 |
ilvD | BPSS0305 | BPSL0969 | BPSS0305 | Similar to Lactococcus lactis dihydroxy-acid dehydratase IlvD or ll1223 SWALL:ILVD_LACLA (SWALL:Q02139) (570 aa) fasta scores: E(): 4.6e-100, 49.63% id in 554 aa, and to Ralstonia solanacearum dihydroxy-acid dehydratase IlvD or rsc2412 or rs02706 SWALL:ILVD_RALSO (SWALL:Q8XWR1) (557 aa) fasta scores: E(): 1.2e-186, 86.33% id in 556 aa; Belongs to the IlvD/Edd family. | Similar to Bacillus subtilis ketol-acid reductoisomerase IlvC SWALL:ILVC_BACSU (SWALL:P37253) (342 aa) fasta scores: E(): 7e-27, 36.91% id in 298 aa, and to Neisseria meningitidis ketol-acid reductoisomerase nma1763 SWALL:ILVC_NEIMA (SWALL:Q9JTI3) (337 aa) fasta scores: E(): 9.9e-31, 35.71% id in 322 aa. | 0.992 |
ilvD | ilvC | BPSL0969 | BPSL1198 | Similar to Lactococcus lactis dihydroxy-acid dehydratase IlvD or ll1223 SWALL:ILVD_LACLA (SWALL:Q02139) (570 aa) fasta scores: E(): 4.6e-100, 49.63% id in 554 aa, and to Ralstonia solanacearum dihydroxy-acid dehydratase IlvD or rsc2412 or rs02706 SWALL:ILVD_RALSO (SWALL:Q8XWR1) (557 aa) fasta scores: E(): 1.2e-186, 86.33% id in 556 aa; Belongs to the IlvD/Edd family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.995 |