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hemC hemC BPSL1016 BPSL1016 hemB hemB hemE hemE BPSS1245 BPSS1245 hemA hemA BPSL0961 BPSL0961 hemL hemL BPSL1017 BPSL1017 cobQ cobQ cbiD cbiD
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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[Homology]
Score
hemCPutative porphobilinogen deaminase protein; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (329 aa)    
Predicted Functional Partners:
BPSL1016
Full length similar to Ralstonia solanacearum probable bifunctional: uroporphyrin-III C-methyltransferase and uroporphyrinogen-III synthase transmembrane protein rsc2356 or rs01190 SWALL:Q8XWW4 (EMBL:AL646069) (695 aa) fasta scores: E(): 1.8e-32, 39.35% id in 681 aa, and N-terminal region similar to Pseudomonas aeruginosa uroporphyrinogen-III synthase HemD or pa5259 SWALL:HEM4_PSEAE (SWALL:P48246) (251 aa) fasta scores: E(): 0.0084, 36.8% id in 269 aa, and C-terminal region to Escherichia coli putative uroporphyrin-III C-methyltransferase HemX or b3803 SWALL:HEMX_ECOLI (SWALL:P09127) ( [...]
  
 0.999
hemB
Similar to Pseudomonas aeruginosa delta-aminolevulinic acid dehydratase HemB or Pa5243 SWALL:HEM2_PSEAE (SWALL:Q59643) (337 aa) fasta scores: E(): 2e-85, 70.3% id in 330 aa; Belongs to the ALAD family.
 
 0.996
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 0.983
BPSS1245
Similar to Pseudomonas fluorescens uroporphyrin-III c-methyltransferase CobA SWALL:SUMT_PSEFL (SWALL:P37725) (247 aa) fasta scores: E(): 2.2e-32, 46.38% id in 235 aa, and to Xanthomonas campestris uroporphyrin-III c-methyltransferase CysG or xcc2010 SWALL:AAM41299 (EMBL:AE012305) (258 aa) fasta scores: E(): 1.5e-49, 63.55% id in 236 aa, and to Pseudomonas aeruginosa uroporphyrin-III c-methyltransferase CobA or pa1778 SWALL:Q9I2W4 (EMBL:AE004603) (245 aa) fasta scores: E(): 5e-37, 51.31% id in 228 aa; possible alternative start site at codon 41 and codon 44.
  
 0.983
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.976
BPSL0961
Similar to Paracoccus denitrificans uroporphyrin-III C-methyltransferase NirE SWALL:NIRE_PARDE (SWALL:Q51701) (287 aa) fasta scores: E(): 1.3e-24, 43.75% id in 256 aa, and to the C-terminal region of Escherichia coli, and Escherichia coli O157:H7 siroheme synthase [includes: uroporphyrin-iii c-methyltransferase; precorrin-2 oxidase; ferrochelatase] CysG or b3368 or z4729 or ecs4219 SWALL:CYSG_ECOLI (SWALL:P11098) (457 aa) fasta scores: E(): 4.3e-23, 41.35% id in 237 aa.
  
 0.971
hemL
Similar to Neisseria meningitidis glutamate-1-semialdehyde 2,1-aminomutase HemL or nmb1864 SWALL:GSA_NEIMB (SWALL:Q9JXW0) (427 aa) fasta scores: E(): 3.2e-104, 66.82% id in 425 aa, and to Ralstonia solanacearum probable glutamate-1-semialdehyde 2,1-aminomutase protein HemL or rsc0666 or rs01571 SWALL:Q8Y1M4 (EMBL:AL646060) (433 aa) fasta scores: E(): 7.7e-118, 76.69% id in 429 aa.
 
  
 0.897
BPSL1017
Putative porphyrin biosynthesis related protein; Similar to Escherichia coli, and Escherichia coli O157:H7 HemY protein or b3802 or z5316 or ecs4732 SWALL:HEMY_ECOLI (SWALL:P09128) (398 aa) fasta scores: E(): 3.8e-08, 23.27% id in 391 aa, and to Ralstonia solanacearum putative protein porphyrin biosynthesis rsc2355 or rs01191 SWALL:Q8XWW5 (EMBL:AL646069) (397 aa) fasta scores: E(): 2e-69, 50.63% id in 393 aa.
  
  
 0.848
cobQ
Putative cobyric acid synthase protein; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
 
   
 0.768
cbiD
Putative cobalamin biosynthesis-related protein; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
 
   
 0.767
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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