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leuA-2 leuA-2 leuD leuD ilvD ilvD ilvD-2 ilvD-2 leuC leuC ilvE ilvE CA_C2226 CA_C2226 accC accC CA_C2229 CA_C2229 CA_C2499 CA_C2499 ilvN ilvN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
leuA-22-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (558 aa)    
Predicted Functional Partners:
leuD
3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
  
 
 0.991
ilvD
Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
 
 
 0.979
ilvD-2
Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family.
 
 
 0.979
leuC
3-Isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
  
 
 0.969
ilvE
Branched-chain-amino-acid transaminase (ilvE).
  
 0.963
CA_C2226
Enzyme of ILVE/PABC family (branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase).
  
 0.953
accC
Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
  
 
 0.951
CA_C2229
Pyruvate:ferredoxin oxidoreductase.
  
 
 0.948
CA_C2499
Pyruvate ferredoxin oxidoreductase.
  
 
 0.947
ilvN
Acetolactate synthase, small subunit.
 
 
 0.940
Your Current Organism:
Clostridium acetobutylicum
NCBI taxonomy Id: 272562
Other names: C. acetobutylicum ATCC 824, Clostridium acetobutylicum ATCC 824, Clostridium acetobutylicum DSM 792, Clostridium acetobutylicum str. ATCC 824, Clostridium acetobutylicum strain ATCC 824
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