node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ST0467 | fen-1 | STK_04670 | STK_02100 | Mini-chromosome maintenance protein; N-term changed (+414); protein synonym:MCM; protein synonym:replicative DNA helicase; Belongs to the MCM family. | Flap endonuclease-1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] | 0.917 |
ST0467 | orc1-1 | STK_04670 | STK_03050 | Mini-chromosome maintenance protein; N-term changed (+414); protein synonym:MCM; protein synonym:replicative DNA helicase; Belongs to the MCM family. | Orc1/Cdc6 initiator protein 1; Involved in regulation of DNA replication. | 0.981 |
ST0467 | orc1-2 | STK_04670 | STK_04710 | Mini-chromosome maintenance protein; N-term changed (+414); protein synonym:MCM; protein synonym:replicative DNA helicase; Belongs to the MCM family. | Orc1/Cdc6 initiator protein 2; Involved in regulation of DNA replication. | 0.990 |
ST0467 | polB2 | STK_04670 | STK_16800 | Mini-chromosome maintenance protein; N-term changed (+414); protein synonym:MCM; protein synonym:replicative DNA helicase; Belongs to the MCM family. | Protein synonym:DNA polymerase B2. | 0.955 |
ST0467 | priA | STK_04670 | STK_09430 | Mini-chromosome maintenance protein; N-term changed (+414); protein synonym:MCM; protein synonym:replicative DNA helicase; Belongs to the MCM family. | DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] | 0.975 |
ST0467 | priB | STK_04670 | STK_14310 | Mini-chromosome maintenance protein; N-term changed (+414); protein synonym:MCM; protein synonym:replicative DNA helicase; Belongs to the MCM family. | DNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.986 |
ST0467 | rfcS | STK_04670 | STK_04750 | Mini-chromosome maintenance protein; N-term changed (+414); protein synonym:MCM; protein synonym:replicative DNA helicase; Belongs to the MCM family. | Replication factor C small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. | 0.950 |
ST0467 | ssb | STK_04670 | STK_05030 | Mini-chromosome maintenance protein; N-term changed (+414); protein synonym:MCM; protein synonym:replicative DNA helicase; Belongs to the MCM family. | Single-stranded DNA-binding protein; N-terminus of this ORF was identified by Edman sequencing. | 0.965 |
STK_03040 | orc1-1 | STK_03040 | STK_03050 | Hypothetical protein; N-term changed (-45); Belongs to the UPF0215 family. | Orc1/Cdc6 initiator protein 1; Involved in regulation of DNA replication. | 0.854 |
dnaG | fen-1 | STK_20750 | STK_02100 | Exosome subunit DnaG; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | Flap endonuclease-1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] | 0.745 |
dnaG | orc1-1 | STK_20750 | STK_03050 | Exosome subunit DnaG; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | Orc1/Cdc6 initiator protein 1; Involved in regulation of DNA replication. | 0.717 |
dnaG | orc1-2 | STK_20750 | STK_04710 | Exosome subunit DnaG; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | Orc1/Cdc6 initiator protein 2; Involved in regulation of DNA replication. | 0.744 |
dnaG | priA | STK_20750 | STK_09430 | Exosome subunit DnaG; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] | 0.925 |
dnaG | priB | STK_20750 | STK_14310 | Exosome subunit DnaG; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | DNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.836 |
dnaG | rfcS | STK_20750 | STK_04750 | Exosome subunit DnaG; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | Replication factor C small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. | 0.427 |
fen-1 | ST0467 | STK_02100 | STK_04670 | Flap endonuclease-1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] | Mini-chromosome maintenance protein; N-term changed (+414); protein synonym:MCM; protein synonym:replicative DNA helicase; Belongs to the MCM family. | 0.917 |
fen-1 | dnaG | STK_02100 | STK_20750 | Flap endonuclease-1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] | Exosome subunit DnaG; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | 0.745 |
fen-1 | orc1-1 | STK_02100 | STK_03050 | Flap endonuclease-1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] | Orc1/Cdc6 initiator protein 1; Involved in regulation of DNA replication. | 0.763 |
fen-1 | orc1-2 | STK_02100 | STK_04710 | Flap endonuclease-1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] | Orc1/Cdc6 initiator protein 2; Involved in regulation of DNA replication. | 0.709 |
fen-1 | polB2 | STK_02100 | STK_16800 | Flap endonuclease-1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] | Protein synonym:DNA polymerase B2. | 0.918 |