node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PEPE_0687 | PEPE_0692 | PEPE_0687 | PEPE_0692 | Integral membrane protein, interacts with FtsH; Belongs to the BI1 family. | Replicative DNA helicase loader DnaB. | 0.536 |
PEPE_0687 | PEPE_0693 | PEPE_0687 | PEPE_0693 | Integral membrane protein, interacts with FtsH; Belongs to the BI1 family. | Replicative DNA helicase loader DnaI. | 0.534 |
PEPE_0687 | coaE | PEPE_0687 | PEPE_0690 | Integral membrane protein, interacts with FtsH; Belongs to the BI1 family. | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.607 |
PEPE_0687 | murC | PEPE_0687 | PEPE_0686 | Integral membrane protein, interacts with FtsH; Belongs to the BI1 family. | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.655 |
PEPE_0687 | mutM | PEPE_0687 | PEPE_0689 | Integral membrane protein, interacts with FtsH; Belongs to the BI1 family. | DNA-(apurinic or apyrimidinic site) lyase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.609 |
PEPE_0687 | nrdR | PEPE_0687 | PEPE_0691 | Integral membrane protein, interacts with FtsH; Belongs to the BI1 family. | Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.545 |
PEPE_0687 | polA | PEPE_0687 | PEPE_0688 | Integral membrane protein, interacts with FtsH; Belongs to the BI1 family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.703 |
PEPE_0692 | PEPE_0687 | PEPE_0692 | PEPE_0687 | Replicative DNA helicase loader DnaB. | Integral membrane protein, interacts with FtsH; Belongs to the BI1 family. | 0.536 |
PEPE_0692 | PEPE_0693 | PEPE_0692 | PEPE_0693 | Replicative DNA helicase loader DnaB. | Replicative DNA helicase loader DnaI. | 0.969 |
PEPE_0692 | coaE | PEPE_0692 | PEPE_0690 | Replicative DNA helicase loader DnaB. | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.778 |
PEPE_0692 | murC | PEPE_0692 | PEPE_0686 | Replicative DNA helicase loader DnaB. | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.603 |
PEPE_0692 | mutM | PEPE_0692 | PEPE_0689 | Replicative DNA helicase loader DnaB. | DNA-(apurinic or apyrimidinic site) lyase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.844 |
PEPE_0692 | nrdR | PEPE_0692 | PEPE_0691 | Replicative DNA helicase loader DnaB. | Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.911 |
PEPE_0692 | polA | PEPE_0692 | PEPE_0688 | Replicative DNA helicase loader DnaB. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.817 |
PEPE_0692 | thrS | PEPE_0692 | PEPE_0694 | Replicative DNA helicase loader DnaB. | Ser-tRNA(Thr) hydrolase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). | 0.550 |
PEPE_0693 | PEPE_0687 | PEPE_0693 | PEPE_0687 | Replicative DNA helicase loader DnaI. | Integral membrane protein, interacts with FtsH; Belongs to the BI1 family. | 0.534 |
PEPE_0693 | PEPE_0692 | PEPE_0693 | PEPE_0692 | Replicative DNA helicase loader DnaI. | Replicative DNA helicase loader DnaB. | 0.969 |
PEPE_0693 | coaE | PEPE_0693 | PEPE_0690 | Replicative DNA helicase loader DnaI. | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.781 |
PEPE_0693 | murC | PEPE_0693 | PEPE_0686 | Replicative DNA helicase loader DnaI. | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.533 |
PEPE_0693 | mutM | PEPE_0693 | PEPE_0689 | Replicative DNA helicase loader DnaI. | DNA-(apurinic or apyrimidinic site) lyase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.832 |