STRINGSTRING
hisE hisE hisG hisG hisI hisI hisF hisF hisD hisD hisB hisB hisA hisA hisH hisH hisC hisC ribH ribH Arth_1675 Arth_1675
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query proteins and first shell of interactors
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second shell of interactors
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a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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hisEPFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: tfu:Tfu_0175 phosphoribosyl-ATP pyrophosphatase. (113 aa)    
Predicted Functional Partners:
hisG
ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
 
 
 0.999
hisI
phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
 
 
 0.997
hisF
Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
  
 0.991
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
  
 0.982
hisB
PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: blo:BL1297 imidazoleglycerol-phosphate dehydratase.
 
  
 0.981
hisA
KEGG: lxx:Lxx15830 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; TIGRFAM: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis.
 
  
 0.979
hisH
Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.962
hisC
TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: lxx:Lxx15860 histidinol-phosphate aminotransferase 1; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
  
 0.854
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
  
    0.778
Arth_1675
TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: nfa:nfa36010 putative riboflavin synthase alpha subunit.
  
    0.763
Your Current Organism:
Arthrobacter sp. FB24
NCBI taxonomy Id: 290399
Other names: A. sp. FB24
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