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coaD coaD Tbd_0379 Tbd_0379 coaX coaX coaE coaE Tbd_2587 Tbd_2587 Tbd_0377 Tbd_0377 Tbd_0378 Tbd_0378 Tbd_0381 Tbd_0381 Tbd_2698 Tbd_2698 Tbd_0027 Tbd_0027 guaA guaA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
coaDPanththeine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa)    
Predicted Functional Partners:
Tbd_0379
Conserved hypothetical protein 95.
 
  
 0.973
coaX
Putative transcriptional acitvator, Baf; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family.
 
  
 0.946
coaE
dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
    
 0.939
Tbd_2587
DNA/pantothenate metabolism flavoprotein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family.
    
 0.934
Tbd_0377
Insulinase family protein; Belongs to the peptidase M16 family.
     
 0.805
Tbd_0378
Insulinase family protein.
     
 0.805
Tbd_0381
Probable ferredoxin protein.
     
 0.772
Tbd_2698
Probable 3-deoxy-D-manno-octulosonic-acid transferase transmembrane protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family.
    
 0.763
Tbd_0027
NUDIX hydrolase; Belongs to the Nudix hydrolase family.
 
    0.650
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
 
   
 0.644
Your Current Organism:
Thiobacillus denitrificans ATCC 25259
NCBI taxonomy Id: 292415
Other names: T. denitrificans ATCC 25259, Thiobacillus denitrificans str. ATCC 25259, Thiobacillus denitrificans strain ATCC 25259
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