STRINGSTRING
sucC sucC sucD sucD Wbm0448 Wbm0448 Wbm0486 Wbm0486 Wbm0485 Wbm0485 Wbm0600 Wbm0600 Wbm0108 Wbm0108 Wbm0735 Wbm0735 Wbm0747 Wbm0747 Wbm0395 Wbm0395 nuoD nuoD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
sucCSuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa)    
Predicted Functional Partners:
sucD
Succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 0.999
Wbm0448
Succinate dehydrogenase flavoprotein subunit, SdhA; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
  
 0.990
Wbm0486
Succinate dehydrogenase subunit C sdhC.
  
 
 0.989
Wbm0485
Succinate dehydrogenase subunit D sdhD, hydrophobic membrane anchor protein.
  
 
 0.987
Wbm0600
Succinate dehydrogenase Fe-S protein, SdhB; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
  
 0.986
Wbm0108
Dihydrolipoamide acyltransferase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
  
 0.984
Wbm0735
Citrate synthase; Belongs to the citrate synthase family.
  
 
 0.972
Wbm0747
Dihydrolipoamide acyltransferase E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 0.968
Wbm0395
2-oxoglutarate dehydrogenase complex, E1 component.
  
 
 0.941
nuoD
NADH:ubiquinone oxidoreductase chain D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I 49 kDa subunit family.
  
 
 0.866
Your Current Organism:
Wolbachia endosymbiont strain
NCBI taxonomy Id: 292805
Other names: W. endosymbiont strain TRS of Brugia malayi, Wolbachia endosymbiont strain TRS of Brugia malayi, Wolbachia malayi TRS
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