STRINGSTRING
A1E_00140 A1E_00140 A1E_02970 A1E_02970 A1E_01060 A1E_01060 A1E_03400 A1E_03400 A1E_03830 A1E_03830 A1E_03260 A1E_03260 polA polA dut dut A1E_00650 A1E_00650 A1E_00145 A1E_00145 A1E_03845 A1E_03845
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A1E_00140Hypothetical protein; COG1678 Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. (189 aa)    
Predicted Functional Partners:
A1E_02970
Ribonucleotide-diphosphate reductase alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
   
 0.998
A1E_01060
Glutaredoxin, GrxC family protein; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.
    
  0.933
A1E_03400
Thiol:disulfide interchange protein TlpA; COG0526 Thiol-disulfide isomerase and thioredoxins.
   
 
 0.931
A1E_03830
Holliday junction resolvase-like protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family.
  
  
 0.794
A1E_03260
DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 
 0.702
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 
 0.670
dut
Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
   
  
 0.655
A1E_00650
Hypothetical protein; COG2142 Succinate dehydrogenase, hydrophobic anchor subunit.
   
    0.643
A1E_00145
Hypothetical protein.
       0.562
A1E_03845
Hypothetical protein; COG0330 Membrane protease subunits, stomatin/prohibitin homologs.
  
    0.519
Your Current Organism:
Rickettsia canadensis
NCBI taxonomy Id: 293613
Other names: R. canadensis str. McKiel, Rickettsia canadensis str. McKiel, Rickettsia canadensis strain McKiel
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