STRINGSTRING
pepA pepA A1E_00435 A1E_00435 glyA-2 glyA-2 gmk-2 gmk-2 htpG htpG A1E_02355 A1E_02355 A1E_05580 A1E_05580 A1E_00735 A1E_00735 groL groL greA-2 greA-2 secF secF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pepALeucyl aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. (500 aa)    
Predicted Functional Partners:
A1E_00435
COG0436 Aspartate/tyrosine/aromatic aminotransferase.
   
  0.832
glyA-2
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.825
gmk-2
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
    
  0.724
htpG
Heat shock protein 90; Molecular chaperone. Has ATPase activity.
  
    0.519
A1E_02355
Hypothetical protein; COG0006 Xaa-Pro aminopeptidase.
  
 
 0.479
A1E_05580
COG2927 DNA polymerase III, chi subunit.
  
  
 0.462
A1E_00735
Hypothetical protein.
       0.461
groL
Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
 
 0.450
greA-2
Transcription elongation factor GreA; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.
     
 0.428
secF
Preprotein translocase subunit SecF; COG0681 Signal peptidase I; Belongs to the peptidase S26 family.
     
 0.424
Your Current Organism:
Rickettsia canadensis
NCBI taxonomy Id: 293613
Other names: R. canadensis str. McKiel, Rickettsia canadensis str. McKiel, Rickettsia canadensis strain McKiel
Server load: low (16%) [HD]