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ccmE ccmE ccmC ccmC A1C_05515 A1C_05515 ccmA ccmA A1C_02970 A1C_02970 A1C_04570 A1C_04570 ppa ppa A1C_05295 A1C_05295 hemH hemH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ccmECytochrome c-type biogenesis protein CcmE/CycJ; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family. (128 aa)    
Predicted Functional Partners:
ccmC
Heme exporter protein C; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family.
 
 
 0.998
A1C_05515
Cytochrome c-type biogenesis protein CcmF; COG1138 Cytochrome c biogenesis factor.
 
 
 0.952
ccmA
Heme exporter protein A; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.
 
 
 0.891
A1C_02970
Thiol:disulfide interchange protein tlpA; COG0526 Thiol-disulfide isomerase and thioredoxins.
  
  
 0.636
A1C_04570
Sco2 protein precursor; COG1999 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems.
       0.524
ppa
Inorganic pyrophosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
       0.500
A1C_05295
COG0836 Mannose-1-phosphate guanylyltransferase.
     
 0.497
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
     
 0.456
Your Current Organism:
Rickettsia akari
NCBI taxonomy Id: 293614
Other names: R. akari str. Hartford, Rickettsia akari str. Hartford, Rickettsia akari strain Hartford
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