STRINGSTRING
pdgfrb pdgfrb pdgfb pdgfb LOC101063539 LOC101063539 grb2 grb2 LOC101061204 LOC101061204 LOC101075732 LOC101075732 pdgfc pdgfc Pdgfd Pdgfd src src LOC101065281 LOC101065281 plcg2 plcg2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
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Cooccurrence
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[Homology]
Score
pdgfrbPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Required for normal development of the cardiovascular system. Required for normal recruitment of [...] (1129 aa)    
Predicted Functional Partners:
pdgfb
Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family.
   
 0.996
LOC101063539
Platelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family.
    
 0.987
grb2
Growth factor receptor-bound protein 2b.
   
 0.983
LOC101061204
Uncharacterized protein.
   
 0.983
LOC101075732
Uncharacterized protein LOC101075732 isoform X1.
   
 0.969
pdgfc
Platelet derived growth factor c; Belongs to the PDGF/VEGF growth factor family.
    
 0.969
Pdgfd
Platelet derived growth factor d; Belongs to the PDGF/VEGF growth factor family.
    
 0.966
src
Tyrosine-protein kinase.
   
0.956
LOC101065281
Tyrosine-protein kinase.
   
0.956
plcg2
Phosphoinositide phospholipase C.
    
 0.946
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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