node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RPC_1447 | RPC_1693 | RPC_1447 | RPC_1693 | L-threonine ammonia-lyase. | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | 0.944 |
RPC_1447 | RPC_2090 | RPC_1447 | RPC_2090 | L-threonine ammonia-lyase. | Thiamine pyrophosphate enzyme-like TPP-binding. | 0.934 |
RPC_1447 | RPC_3253 | RPC_1447 | RPC_3253 | L-threonine ammonia-lyase. | Acetolactate synthase, small subunit. | 0.984 |
RPC_1447 | RPC_3254 | RPC_1447 | RPC_3254 | L-threonine ammonia-lyase. | Pyridoxal-5'-phosphate-dependent enzyme, beta subunit. | 0.927 |
RPC_1447 | RPC_3255 | RPC_1447 | RPC_3255 | L-threonine ammonia-lyase. | Acetolactate synthase, large subunit. | 0.942 |
RPC_1447 | ilvC | RPC_1447 | RPC_3248 | L-threonine ammonia-lyase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.772 |
RPC_1447 | leuB | RPC_1447 | RPC_0240 | L-threonine ammonia-lyase. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.951 |
RPC_1447 | leuC | RPC_1447 | RPC_0227 | L-threonine ammonia-lyase. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.555 |
RPC_1447 | leuD | RPC_1447 | RPC_0230 | L-threonine ammonia-lyase. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.589 |
RPC_1693 | RPC_1447 | RPC_1693 | RPC_1447 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | L-threonine ammonia-lyase. | 0.944 |
RPC_1693 | RPC_3253 | RPC_1693 | RPC_3253 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | Acetolactate synthase, small subunit. | 0.983 |
RPC_1693 | RPC_3254 | RPC_1693 | RPC_3254 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | Pyridoxal-5'-phosphate-dependent enzyme, beta subunit. | 0.947 |
RPC_1693 | ilvC | RPC_1693 | RPC_3248 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.993 |
RPC_1693 | leuA | RPC_1693 | RPC_3235 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.939 |
RPC_1693 | leuB | RPC_1693 | RPC_0240 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.973 |
RPC_1693 | leuC | RPC_1693 | RPC_0227 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.658 |
RPC_1693 | leuD | RPC_1693 | RPC_0230 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.704 |
RPC_2090 | RPC_1447 | RPC_2090 | RPC_1447 | Thiamine pyrophosphate enzyme-like TPP-binding. | L-threonine ammonia-lyase. | 0.934 |
RPC_2090 | RPC_3253 | RPC_2090 | RPC_3253 | Thiamine pyrophosphate enzyme-like TPP-binding. | Acetolactate synthase, small subunit. | 0.961 |
RPC_2090 | RPC_3254 | RPC_2090 | RPC_3254 | Thiamine pyrophosphate enzyme-like TPP-binding. | Pyridoxal-5'-phosphate-dependent enzyme, beta subunit. | 0.934 |