node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RPC_0056 | RPC_0143 | RPC_0056 | RPC_0143 | Glutamine amidotransferase class-I. | Ham1-like protein. | 0.908 |
RPC_0056 | RPC_0324 | RPC_0056 | RPC_0324 | Glutamine amidotransferase class-I. | Ham1-like protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.908 |
RPC_0056 | RPC_1152 | RPC_0056 | RPC_1152 | Glutamine amidotransferase class-I. | 5'-Nucleotidase-like; Belongs to the 5'-nucleotidase family. | 0.920 |
RPC_0056 | RPC_2752 | RPC_0056 | RPC_2752 | Glutamine amidotransferase class-I. | MazG family protein. | 0.900 |
RPC_0056 | apt | RPC_0056 | RPC_4387 | Glutamine amidotransferase class-I. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.935 |
RPC_0056 | gmk | RPC_0056 | RPC_2305 | Glutamine amidotransferase class-I. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.924 |
RPC_0056 | gpt | RPC_0056 | RPC_3155 | Glutamine amidotransferase class-I. | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 0.935 |
RPC_0056 | guaA | RPC_0056 | RPC_3063 | Glutamine amidotransferase class-I. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.919 |
RPC_0056 | guaB | RPC_0056 | RPC_3071 | Glutamine amidotransferase class-I. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.988 |
RPC_0056 | surE | RPC_0056 | RPC_2519 | Glutamine amidotransferase class-I. | 3'-nucleotidase / 5'-nucleotidase / exopolyphosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.925 |
RPC_0143 | RPC_0056 | RPC_0143 | RPC_0056 | Ham1-like protein. | Glutamine amidotransferase class-I. | 0.908 |
RPC_0143 | RPC_0324 | RPC_0143 | RPC_0324 | Ham1-like protein. | Ham1-like protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.900 |
RPC_0143 | RPC_1152 | RPC_0143 | RPC_1152 | Ham1-like protein. | 5'-Nucleotidase-like; Belongs to the 5'-nucleotidase family. | 0.903 |
RPC_0143 | gpt | RPC_0143 | RPC_3155 | Ham1-like protein. | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 0.920 |
RPC_0143 | guaA | RPC_0143 | RPC_3063 | Ham1-like protein. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.946 |
RPC_0143 | guaB | RPC_0143 | RPC_3071 | Ham1-like protein. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.937 |
RPC_0143 | surE | RPC_0143 | RPC_2519 | Ham1-like protein. | 3'-nucleotidase / 5'-nucleotidase / exopolyphosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.904 |
RPC_0324 | RPC_0056 | RPC_0324 | RPC_0056 | Ham1-like protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamine amidotransferase class-I. | 0.908 |
RPC_0324 | RPC_0143 | RPC_0324 | RPC_0143 | Ham1-like protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Ham1-like protein. | 0.900 |
RPC_0324 | RPC_1152 | RPC_0324 | RPC_1152 | Ham1-like protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 5'-Nucleotidase-like; Belongs to the 5'-nucleotidase family. | 0.903 |