STRINGSTRING
lipB lipB lipA lipA gcvH gcvH Pden_1650 Pden_1650 Pden_2438 Pden_2438 Pden_2904 Pden_2904 Pden_0857 Pden_0857 Pden_1651 Pden_1651 gcvP gcvP Pden_0836 Pden_0836 Pden_2147 Pden_2147
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lipBLipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (218 aa)    
Predicted Functional Partners:
lipA
Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
 
 0.998
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 
 0.859
Pden_1650
PFAM: beta-ketoacyl synthase; KEGG: rsp:RSP_3177 3-oxoacyl-(acyl-carrier-protein) synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
    
 0.822
Pden_2438
KEGG: mlo:mlr2352 3-oxoacyl-(acyl carrier protein) synthase.
    
 0.822
Pden_2904
3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.
    
 0.822
Pden_0857
Enoyl-[acyl-carrier-protein] reductase (NADH); PFAM: short-chain dehydrogenase/reductase SDR; KEGG: sit:TM1040_1147 enoyl-(acyl-carrier-protein) reductase.
     
  0.800
Pden_1651
Enoyl-[acyl-carrier-protein] reductase (NADH); PFAM: short-chain dehydrogenase/reductase SDR; KEGG: rsp:RSP_3176 enoyl-(acyl-carrier protein) reductase (NADH).
     
  0.800
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
 
   
 0.782
Pden_0836
PFAM: beta-ketoacyl synthase; Thioesterase; acyl transferase domain protein; NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; 3-beta hydroxysteroid dehydrogenase/isomerase; phosphopantetheine-binding; KR; KEGG: sil:SPO0849 non-ribosomal peptide synthase.
   
 0.760
Pden_2147
PFAM: beta-lactamase domain protein; KEGG: rsp:RSP_0676 PhnP-like protein.
 
   
 0.700
Your Current Organism:
Paracoccus denitrificans
NCBI taxonomy Id: 318586
Other names: P. denitrificans PD1222, Paracoccus denitrificans PD1222
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.