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bhcA bhcA bhcB bhcB gcvP gcvP Pden_1941 Pden_1941 Pden_0729 Pden_0729 Pden_0512 Pden_0512 glyA glyA Pden_4398 Pden_4398 Pden_4399 Pden_4399 Pden_0515 Pden_0515 Pden_0812 Pden_0812
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
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textmining
co-expression
protein homology
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bhcASerine-glyoxylate aminotransferase apoenzyme; Catalyzes the transamination of glyoxylate into glycine using L-aspartate as the preferred amino group donor. Is essential for the growth of P.denitrificans in the presence of glycolate and glyoxylate since it functions in glyoxylate assimilation via the beta- hydroxyaspartate cycle (BHAC). Can catalyze the reverse reaction in vitro, and also use L-serine and L-glutamate as amino group donor, but with much less efficiency than L-aspartate. (396 aa)    
Predicted Functional Partners:
bhcB
Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; Catalyzes the dehydration of (2R,3S)-beta-hydroxyaspartate ((3S)-3-hydroxy-D-aspartate) into iminosuccinate. Is essential for the growth of P.denitrificans in the presence of glycolate and glyoxylate since it functions in glyoxylate assimilation via the beta- hydroxyaspartate cycle (BHAC).
 
 0.987
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
 
 
 0.948
Pden_1941
Glyoxylate reductase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: jan:Jann_0915 glycolate reductase.
 
 
 0.927
Pden_0729
PFAM: aminotransferase, class V; KEGG: rsp:RSP_0245 serine-pyruvate aminotransferase/aspartate aminotransferase.
  
  
 
0.923
Pden_0512
TIGRFAM: sarcosine oxidase, beta subunit family; PFAM: FAD dependent oxidoreductase; KEGG: rsp:RSP_2686 putative sarcosine oxidase beta subunit.
  
 
 0.922
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.922
Pden_4398
PFAM: FAD linked oxidase domain protein; KEGG: sit:TM1040_2501 FAD linked oxidase-like.
 
 
 0.922
Pden_4399
PFAM: FAD linked oxidase domain protein; KEGG: rsp:RSP_1020 putative glycolate oxidase subunit protein.
 
 
 0.922
Pden_0515
TIGRFAM: sarcosine oxidase, alpha subunit family; PFAM: FAD dependent oxidoreductase; glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: rsp:RSP_2689 putative sarcosine oxidase, alpha subunit; Belongs to the GcvT family.
  
 
 0.920
Pden_0812
KEGG: sil:SPO3353 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase.
   
 0.919
Your Current Organism:
Paracoccus denitrificans
NCBI taxonomy Id: 318586
Other names: P. denitrificans PD1222, Paracoccus denitrificans PD1222
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