node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ppha_2249 | guaA | Ppha_2249 | Ppha_2644 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.968 |
Ppha_2249 | guaB | Ppha_2249 | Ppha_1790 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.936 |
Ppha_2249 | surE | Ppha_2249 | Ppha_2386 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.901 |
apt | gmk | Ppha_0460 | Ppha_0404 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.963 |
apt | guaA | Ppha_0460 | Ppha_2644 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.993 |
apt | guaB | Ppha_0460 | Ppha_1790 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.475 |
apt | pyrG | Ppha_0460 | Ppha_0097 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.487 |
apt | surE | Ppha_0460 | Ppha_2386 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.915 |
argS | gmk | Ppha_2879 | Ppha_0404 | KEGG: pvi:Cvib_1732 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.544 |
argS | guaA | Ppha_2879 | Ppha_2644 | KEGG: pvi:Cvib_1732 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.955 |
argS | lysS | Ppha_2879 | Ppha_1733 | KEGG: pvi:Cvib_1732 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase. | TIGRFAM: lysyl-tRNA synthetase; PFAM: tRNA synthetase class II (D K and N); nucleic acid binding OB-fold tRNA/helicase-type; KEGG: cch:Cag_1176 lysyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.848 |
argS | pyrG | Ppha_2879 | Ppha_0097 | KEGG: pvi:Cvib_1732 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.813 |
argS | tuf | Ppha_2879 | Ppha_0287 | KEGG: pvi:Cvib_1732 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase. | Translation elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. | 0.430 |
gmk | apt | Ppha_0404 | Ppha_0460 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.963 |
gmk | argS | Ppha_0404 | Ppha_2879 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | KEGG: pvi:Cvib_1732 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase. | 0.544 |
gmk | guaA | Ppha_0404 | Ppha_2644 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.964 |
gmk | guaB | Ppha_0404 | Ppha_1790 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.559 |
gmk | pyrG | Ppha_0404 | Ppha_0097 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.459 |
gmk | surE | Ppha_0404 | Ppha_2386 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.913 |
guaA | Ppha_2249 | Ppha_2644 | Ppha_2249 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.968 |