node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Sfum_0003 | Sfum_1986 | Sfum_0003 | Sfum_1986 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: mac:MA0956 6-pyruvoyltetrahydropterin synthase. | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: sat:SYN_01559 queuosine biosynthesis protein. | 0.907 |
Sfum_0003 | queC | Sfum_0003 | Sfum_1984 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: mac:MA0956 6-pyruvoyltetrahydropterin synthase. | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.921 |
Sfum_0003 | queE | Sfum_0003 | Sfum_1985 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: mac:MA0956 6-pyruvoyltetrahydropterin synthase. | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.993 |
Sfum_0003 | queF | Sfum_0003 | Sfum_1983 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: mac:MA0956 6-pyruvoyltetrahydropterin synthase. | GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.840 |
Sfum_1378 | guaA | Sfum_1378 | Sfum_2123 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.694 |
Sfum_1378 | queF | Sfum_1378 | Sfum_1983 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.480 |
Sfum_1378 | ribBA | Sfum_1378 | Sfum_1380 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.999 |
Sfum_1980 | queF | Sfum_1980 | Sfum_1983 | PFAM: Xylose isomerase domain protein TIM barrel; KEGG: sco:SCO6575 hypothetical protein. | GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.445 |
Sfum_1986 | Sfum_0003 | Sfum_1986 | Sfum_0003 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: sat:SYN_01559 queuosine biosynthesis protein. | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: mac:MA0956 6-pyruvoyltetrahydropterin synthase. | 0.907 |
Sfum_1986 | queC | Sfum_1986 | Sfum_1984 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: sat:SYN_01559 queuosine biosynthesis protein. | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.969 |
Sfum_1986 | queE | Sfum_1986 | Sfum_1985 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: sat:SYN_01559 queuosine biosynthesis protein. | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.998 |
Sfum_1986 | queF | Sfum_1986 | Sfum_1983 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: sat:SYN_01559 queuosine biosynthesis protein. | GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.924 |
guaA | Sfum_1378 | Sfum_2123 | Sfum_1378 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.694 |
guaA | queE | Sfum_2123 | Sfum_1985 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.464 |
guaA | queF | Sfum_2123 | Sfum_1983 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.470 |
guaA | ribBA | Sfum_2123 | Sfum_1380 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.754 |
guaA | tgt | Sfum_2123 | Sfum_0565 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...] | 0.754 |
queA | queC | Sfum_0564 | Sfum_1984 | Queuosine biosynthesis protein; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.432 |
queA | queF | Sfum_0564 | Sfum_1983 | Queuosine biosynthesis protein; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.525 |
queA | tgt | Sfum_0564 | Sfum_0565 | Queuosine biosynthesis protein; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...] | 0.998 |