node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rfer_0742 | aroD | Rfer_0742 | Rfer_2381 | Conserved hypothetical protein. | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. | 0.660 |
Rfer_1247 | Rfer_1569 | Rfer_1247 | Rfer_1569 | 3-dehydroquinate synthase. | Prephenate dehydratase / chorismate mutase. | 0.709 |
Rfer_1247 | aroB | Rfer_1247 | Rfer_2926 | 3-dehydroquinate synthase. | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). | 0.925 |
Rfer_1247 | aroC | Rfer_1247 | Rfer_3161 | 3-dehydroquinate synthase. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.945 |
Rfer_1247 | aroD | Rfer_1247 | Rfer_2381 | 3-dehydroquinate synthase. | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. | 0.936 |
Rfer_1247 | aroE | Rfer_1247 | Rfer_3413 | 3-dehydroquinate synthase. | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.707 |
Rfer_1247 | aroK-2 | Rfer_1247 | Rfer_2925 | 3-dehydroquinate synthase. | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.992 |
Rfer_1247 | cmk | Rfer_1247 | Rfer_1567 | 3-dehydroquinate synthase. | 3-phosphoshikimate 1-carboxyvinyltransferase / cytidylate kinase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate; Belongs to the cytidylate kinase family. Type 1 subfamily. | 0.981 |
Rfer_1569 | Rfer_1247 | Rfer_1569 | Rfer_1247 | Prephenate dehydratase / chorismate mutase. | 3-dehydroquinate synthase. | 0.709 |
Rfer_1569 | aroB | Rfer_1569 | Rfer_2926 | Prephenate dehydratase / chorismate mutase. | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). | 0.742 |
Rfer_1569 | aroC | Rfer_1569 | Rfer_3161 | Prephenate dehydratase / chorismate mutase. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.991 |
Rfer_1569 | aroD | Rfer_1569 | Rfer_2381 | Prephenate dehydratase / chorismate mutase. | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. | 0.628 |
Rfer_1569 | aroE | Rfer_1569 | Rfer_3413 | Prephenate dehydratase / chorismate mutase. | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.845 |
Rfer_1569 | aroK-2 | Rfer_1569 | Rfer_2925 | Prephenate dehydratase / chorismate mutase. | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.762 |
Rfer_1569 | cmk | Rfer_1569 | Rfer_1567 | Prephenate dehydratase / chorismate mutase. | 3-phosphoshikimate 1-carboxyvinyltransferase / cytidylate kinase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate; Belongs to the cytidylate kinase family. Type 1 subfamily. | 0.994 |
Rfer_2382 | Rfer_2383 | Rfer_2382 | Rfer_2383 | 4-hydroxybenzoyl-CoA thioesterase. | Alpha/beta hydrolase fold-3. | 0.829 |
Rfer_2382 | aroD | Rfer_2382 | Rfer_2381 | 4-hydroxybenzoyl-CoA thioesterase. | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. | 0.430 |
Rfer_2383 | Rfer_2382 | Rfer_2383 | Rfer_2382 | Alpha/beta hydrolase fold-3. | 4-hydroxybenzoyl-CoA thioesterase. | 0.829 |
Rfer_2383 | aroD | Rfer_2383 | Rfer_2381 | Alpha/beta hydrolase fold-3. | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. | 0.450 |
aroB | Rfer_1247 | Rfer_2926 | Rfer_1247 | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). | 3-dehydroquinate synthase. | 0.925 |