node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rfer_0368 | dcd | Rfer_0368 | Rfer_3293 | Ribonucleoside-triphosphate reductase, anaerobic. | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.907 |
Rfer_0368 | ndk | Rfer_0368 | Rfer_2311 | Ribonucleoside-triphosphate reductase, anaerobic. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.912 |
Rfer_0368 | pyrG | Rfer_0368 | Rfer_2648 | Ribonucleoside-triphosphate reductase, anaerobic. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.909 |
dcd | Rfer_0368 | Rfer_3293 | Rfer_0368 | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. | Ribonucleoside-triphosphate reductase, anaerobic. | 0.907 |
dcd | ndk | Rfer_3293 | Rfer_2311 | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.932 |
dcd | pyrG | Rfer_3293 | Rfer_2648 | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.930 |
guaA | ndk | Rfer_2287 | Rfer_2311 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.620 |
guaA | pnp | Rfer_2287 | Rfer_1489 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 3' exoribonuclease; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. | 0.762 |
guaA | pyrG | Rfer_2287 | Rfer_2648 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.965 |
guaA | rplE | Rfer_2287 | Rfer_4231 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | LSU ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. | 0.476 |
guaA | rplF | Rfer_2287 | Rfer_4228 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | LSU ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. | 0.421 |
guaA | rplW | Rfer_2287 | Rfer_3793 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | LSU ribosomal protein L23P; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. | 0.437 |
guaA | rpsB | Rfer_2287 | Rfer_1989 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | SSU ribosomal protein S2P; Belongs to the universal ribosomal protein uS2 family. | 0.700 |
kdsA | pyrG | Rfer_2649 | Rfer_2648 | 2-dehydro-3-deoxyphosphooctonate aldolase; Belongs to the KdsA family. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.884 |
ndk | Rfer_0368 | Rfer_2311 | Rfer_0368 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Ribonucleoside-triphosphate reductase, anaerobic. | 0.912 |
ndk | dcd | Rfer_2311 | Rfer_3293 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.932 |
ndk | guaA | Rfer_2311 | Rfer_2287 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.620 |
ndk | pyrG | Rfer_2311 | Rfer_2648 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.956 |
ndk | rplE | Rfer_2311 | Rfer_4231 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | LSU ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. | 0.736 |
ndk | rplF | Rfer_2311 | Rfer_4228 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | LSU ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. | 0.780 |