node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Hhal_0827 | bioB | Hhal_0827 | Hhal_0963 | PFAM: aminotransferase class-III; KEGG: aeh:Mlg_0491 acetylornithine transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.826 |
Hhal_0961 | Hhal_0964 | Hhal_0961 | Hhal_0964 | Carboxylesterase BioH (pimeloyl-CoA synthesis); PFAM: alpha/beta hydrolase fold; KEGG: aeh:Mlg_2434 alpha/beta hydrolase fold. | KEGG: aeh:Mlg_2437 competence protein F. | 0.700 |
Hhal_0961 | bioA | Hhal_0961 | Hhal_0932 | Carboxylesterase BioH (pimeloyl-CoA synthesis); PFAM: alpha/beta hydrolase fold; KEGG: aeh:Mlg_2434 alpha/beta hydrolase fold. | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase apoenzyme; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 0.419 |
Hhal_0961 | bioB | Hhal_0961 | Hhal_0963 | Carboxylesterase BioH (pimeloyl-CoA synthesis); PFAM: alpha/beta hydrolase fold; KEGG: aeh:Mlg_2434 alpha/beta hydrolase fold. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.866 |
Hhal_0961 | bioC | Hhal_0961 | Hhal_0960 | Carboxylesterase BioH (pimeloyl-CoA synthesis); PFAM: alpha/beta hydrolase fold; KEGG: aeh:Mlg_2434 alpha/beta hydrolase fold. | Biotin biosynthesis protein BioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. | 0.977 |
Hhal_0961 | bioD | Hhal_0961 | Hhal_0959 | Carboxylesterase BioH (pimeloyl-CoA synthesis); PFAM: alpha/beta hydrolase fold; KEGG: aeh:Mlg_2434 alpha/beta hydrolase fold. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.944 |
Hhal_0961 | bioF | Hhal_0961 | Hhal_0962 | Carboxylesterase BioH (pimeloyl-CoA synthesis); PFAM: alpha/beta hydrolase fold; KEGG: aeh:Mlg_2434 alpha/beta hydrolase fold. | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.992 |
Hhal_0961 | birA | Hhal_0961 | Hhal_0875 | Carboxylesterase BioH (pimeloyl-CoA synthesis); PFAM: alpha/beta hydrolase fold; KEGG: aeh:Mlg_2434 alpha/beta hydrolase fold. | biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.430 |
Hhal_0964 | Hhal_0961 | Hhal_0964 | Hhal_0961 | KEGG: aeh:Mlg_2437 competence protein F. | Carboxylesterase BioH (pimeloyl-CoA synthesis); PFAM: alpha/beta hydrolase fold; KEGG: aeh:Mlg_2434 alpha/beta hydrolase fold. | 0.700 |
Hhal_0964 | bioB | Hhal_0964 | Hhal_0963 | KEGG: aeh:Mlg_2437 competence protein F. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.659 |
Hhal_0964 | bioC | Hhal_0964 | Hhal_0960 | KEGG: aeh:Mlg_2437 competence protein F. | Biotin biosynthesis protein BioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. | 0.650 |
Hhal_0964 | bioD | Hhal_0964 | Hhal_0959 | KEGG: aeh:Mlg_2437 competence protein F. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.634 |
Hhal_0964 | bioF | Hhal_0964 | Hhal_0962 | KEGG: aeh:Mlg_2437 competence protein F. | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.641 |
Hhal_2361 | bioA | Hhal_2361 | Hhal_0932 | TIGRFAM: urea amidolyase related protein; PFAM: biotin/lipoyl attachment domain-containing protein; Allophanate hydrolase subunit 2; Allophanate hydrolase subunit 1; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; RimK domain protein ATP-grasp; KEGG: dar:Daro_0074 allophanate hydrolase subunit 2. | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase apoenzyme; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 0.535 |
Hhal_2361 | bioB | Hhal_2361 | Hhal_0963 | TIGRFAM: urea amidolyase related protein; PFAM: biotin/lipoyl attachment domain-containing protein; Allophanate hydrolase subunit 2; Allophanate hydrolase subunit 1; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; RimK domain protein ATP-grasp; KEGG: dar:Daro_0074 allophanate hydrolase subunit 2. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.665 |
Hhal_2361 | birA | Hhal_2361 | Hhal_0875 | TIGRFAM: urea amidolyase related protein; PFAM: biotin/lipoyl attachment domain-containing protein; Allophanate hydrolase subunit 2; Allophanate hydrolase subunit 1; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; RimK domain protein ATP-grasp; KEGG: dar:Daro_0074 allophanate hydrolase subunit 2. | biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.967 |
argD | bioB | Hhal_0727 | Hhal_0963 | TIGRFAM: acetylornithine and succinylornithine aminotransferases; PFAM: aminotransferase class-III; KEGG: aeh:Mlg_1102 acetylornithine and succinylornithine aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.702 |
argD | bioF | Hhal_0727 | Hhal_0962 | TIGRFAM: acetylornithine and succinylornithine aminotransferases; PFAM: aminotransferase class-III; KEGG: aeh:Mlg_1102 acetylornithine and succinylornithine aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.406 |
bioA | Hhal_0961 | Hhal_0932 | Hhal_0961 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase apoenzyme; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | Carboxylesterase BioH (pimeloyl-CoA synthesis); PFAM: alpha/beta hydrolase fold; KEGG: aeh:Mlg_2434 alpha/beta hydrolase fold. | 0.419 |
bioA | Hhal_2361 | Hhal_0932 | Hhal_2361 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase apoenzyme; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | TIGRFAM: urea amidolyase related protein; PFAM: biotin/lipoyl attachment domain-containing protein; Allophanate hydrolase subunit 2; Allophanate hydrolase subunit 1; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; RimK domain protein ATP-grasp; KEGG: dar:Daro_0074 allophanate hydrolase subunit 2. | 0.535 |