node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Hhal_1247 | Hhal_1248 | Hhal_1247 | Hhal_1248 | PFAM: Biopolymer transport protein ExbD/TolR; KEGG: aeh:Mlg_1435 biopolymer transport protein ExbD/TolR. | PFAM: MotA/TolQ/ExbB proton channel; KEGG: aeh:Mlg_1436 MotA/TolQ/ExbB proton channel. | 0.988 |
Hhal_1247 | kdsB | Hhal_1247 | Hhal_1244 | PFAM: Biopolymer transport protein ExbD/TolR; KEGG: aeh:Mlg_1435 biopolymer transport protein ExbD/TolR. | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 0.853 |
Hhal_1247 | lpxK | Hhal_1247 | Hhal_1245 | PFAM: Biopolymer transport protein ExbD/TolR; KEGG: aeh:Mlg_1435 biopolymer transport protein ExbD/TolR. | lipid-A-disaccharide kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.849 |
Hhal_1247 | msbA-2 | Hhal_1247 | Hhal_1246 | PFAM: Biopolymer transport protein ExbD/TolR; KEGG: aeh:Mlg_1435 biopolymer transport protein ExbD/TolR. | Lipid A ABC exporter, fused ATPase and inner membrane subunits MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. | 0.813 |
Hhal_1248 | Hhal_1247 | Hhal_1248 | Hhal_1247 | PFAM: MotA/TolQ/ExbB proton channel; KEGG: aeh:Mlg_1436 MotA/TolQ/ExbB proton channel. | PFAM: Biopolymer transport protein ExbD/TolR; KEGG: aeh:Mlg_1435 biopolymer transport protein ExbD/TolR. | 0.988 |
Hhal_1248 | kdsB | Hhal_1248 | Hhal_1244 | PFAM: MotA/TolQ/ExbB proton channel; KEGG: aeh:Mlg_1436 MotA/TolQ/ExbB proton channel. | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 0.853 |
Hhal_1248 | lpxA | Hhal_1248 | Hhal_1456 | PFAM: MotA/TolQ/ExbB proton channel; KEGG: aeh:Mlg_1436 MotA/TolQ/ExbB proton channel. | acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.468 |
Hhal_1248 | lpxK | Hhal_1248 | Hhal_1245 | PFAM: MotA/TolQ/ExbB proton channel; KEGG: aeh:Mlg_1436 MotA/TolQ/ExbB proton channel. | lipid-A-disaccharide kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.860 |
Hhal_1248 | msbA-2 | Hhal_1248 | Hhal_1246 | PFAM: MotA/TolQ/ExbB proton channel; KEGG: aeh:Mlg_1436 MotA/TolQ/ExbB proton channel. | Lipid A ABC exporter, fused ATPase and inner membrane subunits MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. | 0.812 |
Hhal_2121 | Hhal_2317 | Hhal_2121 | Hhal_2317 | KEGG: aeh:Mlg_2225 KpsF/GutQ family protein; TIGRFAM: KpsF/GutQ family protein; PFAM: CBS domain containing protein; sugar isomerase (SIS). | Three-deoxy-D-manno-octulosonic-acid transferase domain protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | 0.908 |
Hhal_2121 | kdsB | Hhal_2121 | Hhal_1244 | KEGG: aeh:Mlg_2225 KpsF/GutQ family protein; TIGRFAM: KpsF/GutQ family protein; PFAM: CBS domain containing protein; sugar isomerase (SIS). | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 0.915 |
Hhal_2121 | lpxA | Hhal_2121 | Hhal_1456 | KEGG: aeh:Mlg_2225 KpsF/GutQ family protein; TIGRFAM: KpsF/GutQ family protein; PFAM: CBS domain containing protein; sugar isomerase (SIS). | acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.844 |
Hhal_2121 | lpxB | Hhal_2121 | Hhal_1455 | KEGG: aeh:Mlg_2225 KpsF/GutQ family protein; TIGRFAM: KpsF/GutQ family protein; PFAM: CBS domain containing protein; sugar isomerase (SIS). | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.843 |
Hhal_2121 | lpxC | Hhal_2121 | Hhal_2084 | KEGG: aeh:Mlg_2225 KpsF/GutQ family protein; TIGRFAM: KpsF/GutQ family protein; PFAM: CBS domain containing protein; sugar isomerase (SIS). | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. | 0.830 |
Hhal_2121 | lpxD | Hhal_2121 | Hhal_0088 | KEGG: aeh:Mlg_2225 KpsF/GutQ family protein; TIGRFAM: KpsF/GutQ family protein; PFAM: CBS domain containing protein; sugar isomerase (SIS). | UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.853 |
Hhal_2121 | lpxK | Hhal_2121 | Hhal_1245 | KEGG: aeh:Mlg_2225 KpsF/GutQ family protein; TIGRFAM: KpsF/GutQ family protein; PFAM: CBS domain containing protein; sugar isomerase (SIS). | lipid-A-disaccharide kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.907 |
Hhal_2317 | Hhal_2121 | Hhal_2317 | Hhal_2121 | Three-deoxy-D-manno-octulosonic-acid transferase domain protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | KEGG: aeh:Mlg_2225 KpsF/GutQ family protein; TIGRFAM: KpsF/GutQ family protein; PFAM: CBS domain containing protein; sugar isomerase (SIS). | 0.908 |
Hhal_2317 | kdsB | Hhal_2317 | Hhal_1244 | Three-deoxy-D-manno-octulosonic-acid transferase domain protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 0.984 |
Hhal_2317 | lpxA | Hhal_2317 | Hhal_1456 | Three-deoxy-D-manno-octulosonic-acid transferase domain protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.852 |
Hhal_2317 | lpxB | Hhal_2317 | Hhal_1455 | Three-deoxy-D-manno-octulosonic-acid transferase domain protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.854 |