node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Amuc_0585 | Amuc_0667 | Amuc_0585 | Amuc_0667 | PFAM: Threonine dehydratase domain protein; Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: cya:CYA_0143 threonine dehydratase. | TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase domain protein; KEGG: tth:TTC0866 3-isopropylmalate dehydratase; Belongs to the LeuD family. | 0.487 |
Amuc_0585 | Amuc_0809 | Amuc_0585 | Amuc_0809 | PFAM: Threonine dehydratase domain protein; Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: cya:CYA_0143 threonine dehydratase. | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: ace:Acel_0707 acetolactate synthase 3 regulatory subunit. | 0.963 |
Amuc_0585 | Amuc_1253 | Amuc_0585 | Amuc_1253 | PFAM: Threonine dehydratase domain protein; Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: cya:CYA_0143 threonine dehydratase. | PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: aba:Acid345_3680 glutamate synthase (ferredoxin). | 0.603 |
Amuc_0585 | Amuc_1650 | Amuc_0585 | Amuc_1650 | PFAM: Threonine dehydratase domain protein; Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: cya:CYA_0143 threonine dehydratase. | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: olu:OSTLU_51596 predicted protein. | 0.945 |
Amuc_0585 | ilvC | Amuc_0585 | Amuc_1178 | PFAM: Threonine dehydratase domain protein; Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: cya:CYA_0143 threonine dehydratase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.709 |
Amuc_0585 | ilvD | Amuc_0585 | Amuc_1111 | PFAM: Threonine dehydratase domain protein; Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: cya:CYA_0143 threonine dehydratase. | KEGG: cha:CHAB381_1769 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.930 |
Amuc_0585 | leuB | Amuc_0585 | Amuc_0785 | PFAM: Threonine dehydratase domain protein; Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: cya:CYA_0143 threonine dehydratase. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.944 |
Amuc_0585 | leuC | Amuc_0585 | Amuc_0666 | PFAM: Threonine dehydratase domain protein; Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: cya:CYA_0143 threonine dehydratase. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.453 |
Amuc_0667 | Amuc_0585 | Amuc_0667 | Amuc_0585 | TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase domain protein; KEGG: tth:TTC0866 3-isopropylmalate dehydratase; Belongs to the LeuD family. | PFAM: Threonine dehydratase domain protein; Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: cya:CYA_0143 threonine dehydratase. | 0.487 |
Amuc_0667 | Amuc_0809 | Amuc_0667 | Amuc_0809 | TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase domain protein; KEGG: tth:TTC0866 3-isopropylmalate dehydratase; Belongs to the LeuD family. | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: ace:Acel_0707 acetolactate synthase 3 regulatory subunit. | 0.824 |
Amuc_0667 | Amuc_1253 | Amuc_0667 | Amuc_1253 | TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase domain protein; KEGG: tth:TTC0866 3-isopropylmalate dehydratase; Belongs to the LeuD family. | PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: aba:Acid345_3680 glutamate synthase (ferredoxin). | 0.587 |
Amuc_0667 | Amuc_1650 | Amuc_0667 | Amuc_1650 | TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase domain protein; KEGG: tth:TTC0866 3-isopropylmalate dehydratase; Belongs to the LeuD family. | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: olu:OSTLU_51596 predicted protein. | 0.537 |
Amuc_0667 | Amuc_2039 | Amuc_0667 | Amuc_2039 | TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase domain protein; KEGG: tth:TTC0866 3-isopropylmalate dehydratase; Belongs to the LeuD family. | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: dvl:Dvul_1250 putative alpha-isopropylmalate/homocitrate synthase family transferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.976 |
Amuc_0667 | ilvC | Amuc_0667 | Amuc_1178 | TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase domain protein; KEGG: tth:TTC0866 3-isopropylmalate dehydratase; Belongs to the LeuD family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.910 |
Amuc_0667 | ilvD | Amuc_0667 | Amuc_1111 | TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase domain protein; KEGG: tth:TTC0866 3-isopropylmalate dehydratase; Belongs to the LeuD family. | KEGG: cha:CHAB381_1769 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.790 |
Amuc_0667 | leuA | Amuc_0667 | Amuc_0065 | TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase domain protein; KEGG: tth:TTC0866 3-isopropylmalate dehydratase; Belongs to the LeuD family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.983 |
Amuc_0667 | leuB | Amuc_0667 | Amuc_0785 | TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase domain protein; KEGG: tth:TTC0866 3-isopropylmalate dehydratase; Belongs to the LeuD family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.999 |
Amuc_0667 | leuC | Amuc_0667 | Amuc_0666 | TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase domain protein; KEGG: tth:TTC0866 3-isopropylmalate dehydratase; Belongs to the LeuD family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.999 |
Amuc_0809 | Amuc_0585 | Amuc_0809 | Amuc_0585 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: ace:Acel_0707 acetolactate synthase 3 regulatory subunit. | PFAM: Threonine dehydratase domain protein; Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: cya:CYA_0143 threonine dehydratase. | 0.963 |
Amuc_0809 | Amuc_0667 | Amuc_0809 | Amuc_0667 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: ace:Acel_0707 acetolactate synthase 3 regulatory subunit. | TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase domain protein; KEGG: tth:TTC0866 3-isopropylmalate dehydratase; Belongs to the LeuD family. | 0.824 |