STRINGSTRING
lig lig ligA ligA Mvan_0002 Mvan_0002 ku ku polA polA Mvan_5549 Mvan_5549 Mvan_3438 Mvan_3438 Mvan_2024 Mvan_2024 Mvan_0396 Mvan_0396 Mvan_5542 Mvan_5542 dinB dinB
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ligDNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (534 aa)    
Predicted Functional Partners:
ligA
DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
    
 0.980
Mvan_0002
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.921
ku
DNA end-binding protein Ku; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.841
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.837
Mvan_5549
PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: mmc:Mmcs_4939 ATP dependent DNA ligase.
 
   
 0.831
Mvan_3438
PFAM: 5'-3' exonuclease; SMART: Helix-hairpin-helix domain protein, class 2; KEGG: mpa:MAP1825 5'-3'-exonuclease, putative.
 
 0.773
Mvan_2024
PFAM: carbon starvation protein CstA; KEGG: mmc:Mmcs_1798 carbon starvation protein CstA.
     
 0.758
Mvan_0396
KEGG: mmc:Mmcs_0360 hypothetical protein.
 
   
 0.750
Mvan_5542
KEGG: mmc:Mmcs_4915 hypothetical protein.
   
 0.711
dinB
DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
 
 
 0.698
Your Current Organism:
Mycolicibacterium vanbaalenii
NCBI taxonomy Id: 350058
Other names: M. vanbaalenii PYR-1, Mycobacterium sp. PYR-1, Mycobacterium vanbaalenii DSM 7251, Mycobacterium vanbaalenii PYR-1, Mycolicibacterium vanbaalenii DSM 7251, Mycolicibacterium vanbaalenii PYR-1
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