node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABM44484.1 | lipA | BARBAKC583_0539 | BARBAKC583_0538 | Identified by match to protein family HMM PF03364. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.771 |
ABM44484.1 | lpdA2 | BARBAKC583_0539 | BARBAKC583_0537 | Identified by match to protein family HMM PF03364. | Dihydrolipoamide dehydrogenase; Identified by similarity to SP:P50970; match to protein family HMM PF00070; match to protein family HMM PF00890; match to protein family HMM PF02852; match to protein family HMM PF07992; match to protein family HMM TIGR01350. | 0.569 |
ABM44484.1 | pdhB | BARBAKC583_0539 | BARBAKC583_0535 | Identified by match to protein family HMM PF03364. | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.453 |
gcvH | gcvP | BARBAKC583_1095 | BARBAKC583_1094 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
gcvH | lipA | BARBAKC583_1095 | BARBAKC583_0538 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.897 |
gcvH | lipB | BARBAKC583_1095 | BARBAKC583_0898 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Lipoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.913 |
gcvH | lpdA2 | BARBAKC583_1095 | BARBAKC583_0537 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Dihydrolipoamide dehydrogenase; Identified by similarity to SP:P50970; match to protein family HMM PF00070; match to protein family HMM PF00890; match to protein family HMM PF02852; match to protein family HMM PF07992; match to protein family HMM TIGR01350. | 0.970 |
gcvH | pdhB | BARBAKC583_1095 | BARBAKC583_0535 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.930 |
gcvP | gcvH | BARBAKC583_1094 | BARBAKC583_1095 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
gcvP | guaA | BARBAKC583_1094 | BARBAKC583_0344 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.668 |
gcvP | lipA | BARBAKC583_1094 | BARBAKC583_0538 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.577 |
gcvP | lipB | BARBAKC583_1094 | BARBAKC583_0898 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Lipoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.601 |
gcvP | lpdA2 | BARBAKC583_1094 | BARBAKC583_0537 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Dihydrolipoamide dehydrogenase; Identified by similarity to SP:P50970; match to protein family HMM PF00070; match to protein family HMM PF00890; match to protein family HMM PF02852; match to protein family HMM PF07992; match to protein family HMM TIGR01350. | 0.955 |
gcvP | pdhB | BARBAKC583_1094 | BARBAKC583_0535 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.749 |
guaA | gcvP | BARBAKC583_0344 | BARBAKC583_1094 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.668 |
guaA | lipA | BARBAKC583_0344 | BARBAKC583_0538 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.498 |
guaA | nadE | BARBAKC583_0344 | BARBAKC583_0606 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.633 |
guaA | obg | BARBAKC583_0344 | BARBAKC583_0317 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | GTP-binding protein Obg/CgtA; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | 0.478 |
lipA | ABM44484.1 | BARBAKC583_0538 | BARBAKC583_0539 | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Identified by match to protein family HMM PF03364. | 0.771 |
lipA | gcvH | BARBAKC583_0538 | BARBAKC583_1095 | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.897 |