node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Pnap_0825 | rnhB | Pnap_0825 | Pnap_1772 | NAD-dependent formate dehydrogenase flavoprotein subunit; PFAM: Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit; KEGG: rfr:Rfer_3270 NADH dehydrogenase (quinone). | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.833 |
Pnap_1767 | Pnap_1773 | Pnap_1767 | Pnap_1773 | PFAM: outer membrane chaperone Skp (OmpH); KEGG: pol:Bpro_2686 outer membrane chaperone Skp (OmpH); Belongs to the skp family. | PFAM: tRNA/rRNA methyltransferase (SpoU); KEGG: pol:Bpro_2680 tRNA/rRNA methyltransferase (SpoU). | 0.692 |
Pnap_1767 | fabZ | Pnap_1767 | Pnap_1769 | PFAM: outer membrane chaperone Skp (OmpH); KEGG: pol:Bpro_2686 outer membrane chaperone Skp (OmpH); Belongs to the skp family. | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | 0.833 |
Pnap_1767 | lpxA | Pnap_1767 | Pnap_1770 | PFAM: outer membrane chaperone Skp (OmpH); KEGG: pol:Bpro_2686 outer membrane chaperone Skp (OmpH); Belongs to the skp family. | acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.817 |
Pnap_1767 | lpxB | Pnap_1767 | Pnap_1771 | PFAM: outer membrane chaperone Skp (OmpH); KEGG: pol:Bpro_2686 outer membrane chaperone Skp (OmpH); Belongs to the skp family. | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.710 |
Pnap_1767 | lpxD | Pnap_1767 | Pnap_1768 | PFAM: outer membrane chaperone Skp (OmpH); KEGG: pol:Bpro_2686 outer membrane chaperone Skp (OmpH); Belongs to the skp family. | UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.949 |
Pnap_1767 | rnhB | Pnap_1767 | Pnap_1772 | PFAM: outer membrane chaperone Skp (OmpH); KEGG: pol:Bpro_2686 outer membrane chaperone Skp (OmpH); Belongs to the skp family. | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.704 |
Pnap_1773 | Pnap_1767 | Pnap_1773 | Pnap_1767 | PFAM: tRNA/rRNA methyltransferase (SpoU); KEGG: pol:Bpro_2680 tRNA/rRNA methyltransferase (SpoU). | PFAM: outer membrane chaperone Skp (OmpH); KEGG: pol:Bpro_2686 outer membrane chaperone Skp (OmpH); Belongs to the skp family. | 0.692 |
Pnap_1773 | fabZ | Pnap_1773 | Pnap_1769 | PFAM: tRNA/rRNA methyltransferase (SpoU); KEGG: pol:Bpro_2680 tRNA/rRNA methyltransferase (SpoU). | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | 0.786 |
Pnap_1773 | lpxA | Pnap_1773 | Pnap_1770 | PFAM: tRNA/rRNA methyltransferase (SpoU); KEGG: pol:Bpro_2680 tRNA/rRNA methyltransferase (SpoU). | acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.857 |
Pnap_1773 | lpxB | Pnap_1773 | Pnap_1771 | PFAM: tRNA/rRNA methyltransferase (SpoU); KEGG: pol:Bpro_2680 tRNA/rRNA methyltransferase (SpoU). | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.874 |
Pnap_1773 | lpxD | Pnap_1773 | Pnap_1768 | PFAM: tRNA/rRNA methyltransferase (SpoU); KEGG: pol:Bpro_2680 tRNA/rRNA methyltransferase (SpoU). | UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.781 |
Pnap_1773 | rnhB | Pnap_1773 | Pnap_1772 | PFAM: tRNA/rRNA methyltransferase (SpoU); KEGG: pol:Bpro_2680 tRNA/rRNA methyltransferase (SpoU). | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.883 |
Pnap_4118 | rnhB | Pnap_4118 | Pnap_1772 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.890 |
Pnap_4118 | thyA | Pnap_4118 | Pnap_2772 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.855 |
fabZ | Pnap_1767 | Pnap_1769 | Pnap_1767 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | PFAM: outer membrane chaperone Skp (OmpH); KEGG: pol:Bpro_2686 outer membrane chaperone Skp (OmpH); Belongs to the skp family. | 0.833 |
fabZ | Pnap_1773 | Pnap_1769 | Pnap_1773 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | PFAM: tRNA/rRNA methyltransferase (SpoU); KEGG: pol:Bpro_2680 tRNA/rRNA methyltransferase (SpoU). | 0.786 |
fabZ | lpxA | Pnap_1769 | Pnap_1770 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.997 |
fabZ | lpxB | Pnap_1769 | Pnap_1771 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.896 |
fabZ | lpxD | Pnap_1769 | Pnap_1768 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.995 |