STRINGSTRING
miaB miaB miaA miaA lpdA lpdA ybeY ybeY metG metG leuS leuS ygfZ ygfZ lysA lysA prfB prfB holA holA thdF thdF
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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miaBBifunctional enzyme involved in thiolation and methylation of tRNA; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (435 aa)    
Predicted Functional Partners:
miaA
Delta(2)-isopentenylpyrophosphate tRNA-adenosine transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family.
  
 0.977
lpdA
Pyruvate and 2-oxoglutarate dehydrogenase E3 component (dihydrolipoamide dehydrogenase); COG_category C;COG_number COG1249; LpdA.
      
 0.887
ybeY
Predicted metal-dependent hydrolase; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
 
    0.740
metG
methionyl-tRNA synthetase; COG_category J;COG_number COG0143; MetG; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
  
 0.693
leuS
leucyl-tRNA synthetase; COG_category J;COG_number COG0495; LeuS; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
    0.618
ygfZ
Predicted folate-dependent regulatory protein involved in one-carbon metabolism; COG_category R;COG_number COG0354; YgfZ; Belongs to the GcvT family.
     
 0.572
lysA
Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine.
       0.564
prfB
Peptide chain release factor RF-2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
  
    0.539
holA
DNA polymerase III, d subunit; COG_category L;COG_number COG1466; HolA.
       0.496
thdF
GTP-binding protein; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
   
  
 0.493
Your Current Organism:
Buchnera aphidicola BCc
NCBI taxonomy Id: 372461
Other names: B. aphidicola BCc, Buchnera aphidicola str. Cc (Cinara cedri)
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