node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
efp | hisI | BCc_012 | BCc_070 | Elongation factor P; Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-35 is required for alleviation; Belongs to the elongation factor P family. | phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase; COG_category E;COG_number COG0139, COG0140; HisI; In the N-terminal section; belongs to the PRA-CH family. | 0.662 |
efp | ilvD | BCc_012 | BCc_389 | Elongation factor P; Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-35 is required for alleviation; Belongs to the elongation factor P family. | Dihydroxy-acid dehydratase; COG_category EG;COG_number COG0129; IlvD; Belongs to the IlvD/Edd family. | 0.868 |
efp | pheA | BCc_012 | BCc_244 | Elongation factor P; Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-35 is required for alleviation; Belongs to the elongation factor P family. | Bifunctional chorismate mutase P/prephenate dehydratase; COG_category E;COG_number COG0077, COG1605; mutase N-terminal domain and dehydratase C-terminal domain; PheA. | 0.854 |
efp | pta | BCc_012 | BCc_115 | Elongation factor P; Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-35 is required for alleviation; Belongs to the elongation factor P family. | Phosphate acetyltransferase; COG_category C;COG_number COG0280; Pta. | 0.630 |
efp | thrA | BCc_012 | BCc_127 | Elongation factor P; Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-35 is required for alleviation; Belongs to the elongation factor P family. | Aspartokinase I / homoserine dehydrogenase I; COG_category E;COG_number COG0460, COG0527; ThrA; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.854 |
hisI | efp | BCc_070 | BCc_012 | phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase; COG_category E;COG_number COG0139, COG0140; HisI; In the N-terminal section; belongs to the PRA-CH family. | Elongation factor P; Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-35 is required for alleviation; Belongs to the elongation factor P family. | 0.662 |
hisI | ilvC | BCc_070 | BCc_388 | phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase; COG_category E;COG_number COG0139, COG0140; HisI; In the N-terminal section; belongs to the PRA-CH family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.571 |
hisI | ilvD | BCc_070 | BCc_389 | phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase; COG_category E;COG_number COG0139, COG0140; HisI; In the N-terminal section; belongs to the PRA-CH family. | Dihydroxy-acid dehydratase; COG_category EG;COG_number COG0129; IlvD; Belongs to the IlvD/Edd family. | 0.703 |
hisI | ilvI | BCc_070 | BCc_139 | phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase; COG_category E;COG_number COG0139, COG0140; HisI; In the N-terminal section; belongs to the PRA-CH family. | Acetolactate synthase III, large subunit; COG_category E;COG_number COG0028; IlvI. | 0.556 |
hisI | pheA | BCc_070 | BCc_244 | phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase; COG_category E;COG_number COG0139, COG0140; HisI; In the N-terminal section; belongs to the PRA-CH family. | Bifunctional chorismate mutase P/prephenate dehydratase; COG_category E;COG_number COG0077, COG1605; mutase N-terminal domain and dehydratase C-terminal domain; PheA. | 0.800 |
hisI | pta | BCc_070 | BCc_115 | phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase; COG_category E;COG_number COG0139, COG0140; HisI; In the N-terminal section; belongs to the PRA-CH family. | Phosphate acetyltransferase; COG_category C;COG_number COG0280; Pta. | 0.595 |
hisI | thrA | BCc_070 | BCc_127 | phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase; COG_category E;COG_number COG0139, COG0140; HisI; In the N-terminal section; belongs to the PRA-CH family. | Aspartokinase I / homoserine dehydrogenase I; COG_category E;COG_number COG0460, COG0527; ThrA; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.971 |
ilvC | hisI | BCc_388 | BCc_070 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase; COG_category E;COG_number COG0139, COG0140; HisI; In the N-terminal section; belongs to the PRA-CH family. | 0.571 |
ilvC | ilvD | BCc_388 | BCc_389 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Dihydroxy-acid dehydratase; COG_category EG;COG_number COG0129; IlvD; Belongs to the IlvD/Edd family. | 0.999 |
ilvC | ilvH | BCc_388 | BCc_138 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Acetolactate synthase III, small subunit; COG_category E;COG_number COG0440; IlvH. | 0.997 |
ilvC | ilvI | BCc_388 | BCc_139 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Acetolactate synthase III, large subunit; COG_category E;COG_number COG0028; IlvI. | 0.996 |
ilvC | pheA | BCc_388 | BCc_244 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Bifunctional chorismate mutase P/prephenate dehydratase; COG_category E;COG_number COG0077, COG1605; mutase N-terminal domain and dehydratase C-terminal domain; PheA. | 0.836 |
ilvC | pta | BCc_388 | BCc_115 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Phosphate acetyltransferase; COG_category C;COG_number COG0280; Pta. | 0.448 |
ilvC | thrA | BCc_388 | BCc_127 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Aspartokinase I / homoserine dehydrogenase I; COG_category E;COG_number COG0460, COG0527; ThrA; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.815 |
ilvD | efp | BCc_389 | BCc_012 | Dihydroxy-acid dehydratase; COG_category EG;COG_number COG0129; IlvD; Belongs to the IlvD/Edd family. | Elongation factor P; Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-35 is required for alleviation; Belongs to the elongation factor P family. | 0.868 |