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nhaA nhaA mscL mscL nhaR nhaR kefB kefB AHA_1942 AHA_1942 dsbB dsbB aqpZ aqpZ lgt lgt nhaB nhaB thyA thyA AHA_0073 AHA_0073
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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nhaANa+/H+ antiporter NhaA; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family. (396 aa)    
Predicted Functional Partners:
mscL
Large conductance mechanosensitive channel protein; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
     
 0.687
nhaR
Transcriptional activator protein NhaR; Identified by similarity to SP:P0A9G2; match to protein family HMM PF00126; Belongs to the LysR transcriptional regulatory family.
  
  
 0.642
kefB
Glutathione-regulated potassium-efflux system protein KefB; Identified by similarity to SP:P45522; match to protein family HMM PF00999; match to protein family HMM PF02254; match to protein family HMM TIGR00932; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.
 
   
 0.551
AHA_1942
Putative formate transporter FocA; Identified by similarity to SP:P21501; match to protein family HMM PF01226; match to protein family HMM TIGR00790.
      
 0.529
dsbB
Disulfide bond formation protein DsbB; Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein; Belongs to the DsbB family.
      
 0.529
aqpZ
Aquaporin Z; Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity; Belongs to the MIP/aquaporin (TC 1.A.8) family.
      
 0.456
lgt
Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family.
       0.454
nhaB
Na+/H+ antiporter NhaB; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
  
   
 0.449
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
       0.447
AHA_0073
Regulatory protein, LysR:LysR, substrate-binding; Identified by match to protein family HMM PF00126; match to protein family HMM PF03466; Belongs to the LysR transcriptional regulatory family.
  
  
 0.441
Your Current Organism:
Aeromonas hydrophila
NCBI taxonomy Id: 380703
Other names: A. hydrophila subsp. hydrophila ATCC 7966, Aeromonas hydrophila subsp. hydrophila ATCC 7966, Aeromonas hydrophila subsp. hydrophila str. ATCC 7966, Aeromonas hydrophila subsp. hydrophila strain ATCC 7966
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