node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK61111.1 | ABK62676.1 | NT01CX_0865 | NT01CX_0863 | S4 domain protein; Identified by match to protein family HMM PF01479. | Conserved hypothetical protein. | 0.756 |
ABK61111.1 | dnaA | NT01CX_0865 | NT01CX_0867 | S4 domain protein; Identified by match to protein family HMM PF01479. | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | 0.715 |
ABK61111.1 | dnaN | NT01CX_0865 | NT01CX_0866 | S4 domain protein; Identified by match to protein family HMM PF01479. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.858 |
ABK61111.1 | gyrA | NT01CX_0865 | NT01CX_0861 | S4 domain protein; Identified by match to protein family HMM PF01479. | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.685 |
ABK61111.1 | gyrB | NT01CX_0865 | NT01CX_0862 | S4 domain protein; Identified by match to protein family HMM PF01479. | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.717 |
ABK61111.1 | recF | NT01CX_0865 | NT01CX_0864 | S4 domain protein; Identified by match to protein family HMM PF01479. | recF protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. | 0.899 |
ABK62170.1 | dnaA | NT01CX_2326 | NT01CX_0867 | DNA topoisomerase IV subunit B; Identified by match to protein family HMM PF00204; match to protein family HMM PF00986; match to protein family HMM PF02518. | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | 0.465 |
ABK62170.1 | dnaN | NT01CX_2326 | NT01CX_0866 | DNA topoisomerase IV subunit B; Identified by match to protein family HMM PF00204; match to protein family HMM PF00986; match to protein family HMM PF02518. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.682 |
ABK62170.1 | gyrA | NT01CX_2326 | NT01CX_0861 | DNA topoisomerase IV subunit B; Identified by match to protein family HMM PF00204; match to protein family HMM PF00986; match to protein family HMM PF02518. | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.988 |
ABK62170.1 | polA | NT01CX_2326 | NT01CX_1677 | DNA topoisomerase IV subunit B; Identified by match to protein family HMM PF00204; match to protein family HMM PF00986; match to protein family HMM PF02518. | DNA polymerase I, polA; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.600 |
ABK62170.1 | recF | NT01CX_2326 | NT01CX_0864 | DNA topoisomerase IV subunit B; Identified by match to protein family HMM PF00204; match to protein family HMM PF00986; match to protein family HMM PF02518. | recF protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. | 0.731 |
ABK62676.1 | ABK61111.1 | NT01CX_0863 | NT01CX_0865 | Conserved hypothetical protein. | S4 domain protein; Identified by match to protein family HMM PF01479. | 0.756 |
ABK62676.1 | dnaA | NT01CX_0863 | NT01CX_0867 | Conserved hypothetical protein. | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | 0.544 |
ABK62676.1 | dnaN | NT01CX_0863 | NT01CX_0866 | Conserved hypothetical protein. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.701 |
ABK62676.1 | gyrA | NT01CX_0863 | NT01CX_0861 | Conserved hypothetical protein. | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.792 |
ABK62676.1 | gyrB | NT01CX_0863 | NT01CX_0862 | Conserved hypothetical protein. | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.834 |
ABK62676.1 | recF | NT01CX_0863 | NT01CX_0864 | Conserved hypothetical protein. | recF protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. | 0.857 |
dnaA | ABK61111.1 | NT01CX_0867 | NT01CX_0865 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | S4 domain protein; Identified by match to protein family HMM PF01479. | 0.715 |
dnaA | ABK62170.1 | NT01CX_0867 | NT01CX_2326 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | DNA topoisomerase IV subunit B; Identified by match to protein family HMM PF00204; match to protein family HMM PF00986; match to protein family HMM PF02518. | 0.465 |
dnaA | ABK62676.1 | NT01CX_0867 | NT01CX_0863 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | Conserved hypothetical protein. | 0.544 |