STRINGSTRING
fhs fhs folD folD purH purH ABK62163.1 ABK62163.1 glyA glyA ABK61675.1 ABK61675.1 purN purN purD purD thyX thyX guaA guaA cooS cooS
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second shell of interactors
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Predicted Interactions
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textmining
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Score
fhsFormate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. (556 aa)    
Predicted Functional Partners:
folD
Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
 
 
 0.998
purH
Bifunctional purine biosynthesis protein PurH; Identified by match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355.
  
 0.980
ABK62163.1
Formiminotransferase- cyclodeaminase/formiminotetrahydrofolate cyclodeaminase, putative; Identified by match to protein family HMM PF04961.
 
  
 0.979
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.975
ABK61675.1
5-methyltetrahydrofolate--homocysteine methyltransferase, putative; Identified by match to protein family HMM PF00809; match to protein family HMM PF02310; match to protein family HMM PF02574; match to protein family HMM PF02607.
  
 
 0.970
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
  
 0.968
purD
Phosphoribosylformylglycinamidine synthase; Identified by match to protein family HMM PF01071; match to protein family HMM PF02769; match to protein family HMM PF02842; match to protein family HMM PF02843; match to protein family HMM PF02844; match to protein family HMM TIGR00877; match to protein family HMM TIGR01857; Belongs to the GARS family.
  
 
 0.965
thyX
Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
    
  0.902
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
  
 0.801
cooS
Carbon-monoxide dehydrogenase, catalytic subunit; Identified by match to protein family HMM PF03063; match to protein family HMM TIGR01702.
     
 0.791
Your Current Organism:
Clostridium novyi
NCBI taxonomy Id: 386415
Other names: C. novyi NT, Clostridium novyi NT, Clostridium novyi str. NT, Clostridium novyi strain NT, Clostridium novyi-NT
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