node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LVIS_0785 | LVIS_1271 | LVIS_0785 | LVIS_1271 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine cleavage system H protein (lipoate-binding). | 0.525 |
LVIS_0785 | LVIS_1951 | LVIS_0785 | LVIS_1951 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine cleavage system H protein (lipoate-binding). | 0.525 |
LVIS_0785 | fhs | LVIS_0785 | LVIS_0834 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.922 |
LVIS_0785 | fmt | LVIS_0785 | LVIS_0965 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.921 |
LVIS_0785 | glyA | LVIS_0785 | LVIS_1287 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.988 |
LVIS_0785 | thyA | LVIS_0785 | LVIS_0784 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.998 |
LVIS_1271 | LVIS_0785 | LVIS_1271 | LVIS_0785 | Glycine cleavage system H protein (lipoate-binding). | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.525 |
LVIS_1271 | LVIS_1407 | LVIS_1271 | LVIS_1407 | Glycine cleavage system H protein (lipoate-binding). | Dihydrolipoamide dehydrogenase. | 0.946 |
LVIS_1271 | LVIS_1951 | LVIS_1271 | LVIS_1951 | Glycine cleavage system H protein (lipoate-binding). | Glycine cleavage system H protein (lipoate-binding). | 0.917 |
LVIS_1271 | folD | LVIS_1271 | LVIS_0978 | Glycine cleavage system H protein (lipoate-binding). | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.658 |
LVIS_1271 | glyA | LVIS_1271 | LVIS_1287 | Glycine cleavage system H protein (lipoate-binding). | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.945 |
LVIS_1271 | thyA | LVIS_1271 | LVIS_0784 | Glycine cleavage system H protein (lipoate-binding). | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.550 |
LVIS_1288 | glyA | LVIS_1288 | LVIS_1287 | Translation factor SUA5; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.935 |
LVIS_1407 | LVIS_1271 | LVIS_1407 | LVIS_1271 | Dihydrolipoamide dehydrogenase. | Glycine cleavage system H protein (lipoate-binding). | 0.946 |
LVIS_1407 | LVIS_1951 | LVIS_1407 | LVIS_1951 | Dihydrolipoamide dehydrogenase. | Glycine cleavage system H protein (lipoate-binding). | 0.913 |
LVIS_1407 | glyA | LVIS_1407 | LVIS_1287 | Dihydrolipoamide dehydrogenase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.916 |
LVIS_1951 | LVIS_0785 | LVIS_1951 | LVIS_0785 | Glycine cleavage system H protein (lipoate-binding). | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.525 |
LVIS_1951 | LVIS_1271 | LVIS_1951 | LVIS_1271 | Glycine cleavage system H protein (lipoate-binding). | Glycine cleavage system H protein (lipoate-binding). | 0.917 |
LVIS_1951 | LVIS_1407 | LVIS_1951 | LVIS_1407 | Glycine cleavage system H protein (lipoate-binding). | Dihydrolipoamide dehydrogenase. | 0.913 |
LVIS_1951 | folD | LVIS_1951 | LVIS_0978 | Glycine cleavage system H protein (lipoate-binding). | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.658 |