node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Smal_0506 | dcd | Smal_0506 | Smal_2869 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.644 |
Smal_0664 | dcd | Smal_0664 | Smal_2869 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.416 |
Smal_0664 | dut | Smal_0664 | Smal_0285 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.430 |
Smal_0664 | tmk | Smal_0664 | Smal_0877 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.410 |
Smal_2870 | dcd | Smal_2870 | Smal_2869 | Conserved hypothetical protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.737 |
Smal_3078 | dcd | Smal_3078 | Smal_2869 | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; KEGG: xom:XOO_1693 nucleoside triphosphate pyrophosphohydrolase. | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.916 |
Smal_3078 | ndk | Smal_3078 | Smal_1656 | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; KEGG: xom:XOO_1693 nucleoside triphosphate pyrophosphohydrolase. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.900 |
Smal_3078 | pyrG | Smal_3078 | Smal_1448 | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; KEGG: xom:XOO_1693 nucleoside triphosphate pyrophosphohydrolase. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.907 |
bamE | dcd | Smal_1593 | Smal_2869 | SmpA/OmlA domain protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.534 |
coaD | dcd | Smal_1550 | Smal_2869 | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.485 |
dcd | Smal_0506 | Smal_2869 | Smal_0506 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. | 0.644 |
dcd | Smal_0664 | Smal_2869 | Smal_0664 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.416 |
dcd | Smal_2870 | Smal_2869 | Smal_2870 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | Conserved hypothetical protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. | 0.737 |
dcd | Smal_3078 | Smal_2869 | Smal_3078 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; KEGG: xom:XOO_1693 nucleoside triphosphate pyrophosphohydrolase. | 0.916 |
dcd | bamE | Smal_2869 | Smal_1593 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | SmpA/OmlA domain protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. | 0.534 |
dcd | coaD | Smal_2869 | Smal_1550 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.485 |
dcd | dut | Smal_2869 | Smal_0285 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.922 |
dcd | ndk | Smal_2869 | Smal_1656 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.925 |
dcd | pyrG | Smal_2869 | Smal_1448 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.923 |
dcd | tmk | Smal_2869 | Smal_0877 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.494 |